This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1886 Excerpt: ...trace of it to be discovered, nor any inflammatory changes to be verified. These experiments prove that chemically pure uric acid and its solution in phosphate of soda have an influence on certain tissues in a high degree injurious to their nutrition, which can be most easily and conveniently followed in the cornea. The course of the keratitic process leaves H no room for doubt that it could not have been due to the influence of septic matter; this is also shown without the slightest ambiguity by the simultaneous control injection in the other eye with the same syringe of the solution of phosphate of soda or of the mixture with magnesia in suspension. If I now add to this that parenchymatous injections with a two-per cent. solution of urea into the cornea of rabbits were absolutely without irritation, the conclusion does not admit of doubt that uric acid has an especial irritant action on the tissue of the cornea of rabbits. I have now made similar experimencs on the cornea of rabbits with a series of other products of metamorphosis, xanthine, guanine, kreatine, and hippuric acid. The two first, as is known, are very closely allied in their chemical constitution to uric acid. But the experiments were all negative. The hippuric acid only caused a cloudiness that remained some days in the neighbourhood of the puncture. This was not present, however, when the acid two-per cent, solution of hippuric acid, which was warmed previous to injection, was first neutralised by soda. All these solutions, after injection into the corneal tissue, cause no other changes than take place after the injection of a five-per cent. solution of phosphate of soda, the effect of which has been described above. The solution of kreatine was neutral, whilst in the case of the kreatinin...