Now in resplendent color, the new edition continues to define the latest in the scientific understanding of the brain, the nervous system, and human behavior. Each chapter is thoroughly revised and includes the impact of molecular biology in the mechanisms underlying developmental processes and in the pathogenesis of disease. Important features to this edition include a new chapter - Genes and Behavior; a complete updating of development of the nervous system; the genetic basis of neurological and psychiatric disease; cognitive neuroscience of perception, planning, action, motivation and memory; ion channel mechanisms; and much more.

We learn and remember information by modifying synaptic connections in the neuronal networks of our brain. Depending on the type of information being stored, these changes occur in different regions and different circuits of the brain. The underlying circuit mechanisms are beginning to be understood. These mechanisms are capable of storing or reconstructing memories for periods ranging up to a lifetime, but they are also error-prone, as memories can be distorted or lost. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines important aspects of the neurobiology of learning and memory. Contributors review the various types of memory and the anatomical architectures and specialized cells involved. The induction of synaptic and cell-wide changes during memory encoding, the transcriptional and translational programs required for memory stabilization, the molecular signals that actively maintain memories, and the activation of neural ensembles during memory retrieval are comprehensively covered. The authors also discuss the model organisms and state-of-the-art technologies used to elucidate these processes. This volume will serve as a valuable reference for all neurobiologists and biomedical scientists as well as for cognitive and computational neuroscientists wishing to explore the remarkable phenomena of learning and memory.