Methods in Neuronal Modeling is the first technical handbook on computational neuroscience. Written for researchers and theoreticians alike, it outlines methods and techniques used for simulating on digital computers the functional properties of single neurons from synapses, dendrites, single cells; and small invertebrate networks to large scale neural networks in the mammalian nervous system. The use of new experimental tools such as selective staining methods, membrane patch electrodes, voltage and calcium-dependent dyes, and multielectrode recordings, together with the, advent of universally available powerful computing, makes it possible to construct detailed and realistic models of neuronal systems. Methods in Neuronal Modeling addresses such questions as what can and should be simulated and what techniques should be used; what experimental parameters are crucial for such simulations, and whether these models may be verified experimentally. Chapters cover simulation of passive dendritic trees, compartmental models of single cells including neurons with a number of different ionic channels, calcium current dynamics, simulations of small invertebrate networks, simulations of the mammalian cortex, connectionists' models, and the use of parallel computers in modeling neural networks. Although the chapters were written by several authors, they are uniform in structure and notation. Detailed examples are given to clarify the different approaches. Each chapter concludes with a description of the model discussed and the details of its implementation on the computer. Christof Koch is an Assistant Professor of Computation and Neural Systems at the California Institute of Technology. Idan Segev is a Lecturer in Neurobiology at the Institute of Life Science, Hebrew University of Jerusalem. Methods in Neuronal Modeling inaugurates the new series in Computational Neuroscience, edited by Terrence J. Sejnowski and Tomaso Poggio. A Bradford Book.

Groundbreaking research over the last 10 years has given rise to the hologenome concept of evolution. This concept posits that the holobiont (host plus all of its associated microorganisms) and its hologenome (sum of the genetic information of the host and its symbiotic microorganisms), acting in concert, function as a unique biological entity and therefore as a level of selection in evolution. All animals and plants harbor abundant and diverse microbiota, including viruses. Often the amount of symbiotic microorganisms and their combined genetic information far exceed that of their host. The microbiota with its microbiome, together with the host genome, can be transmitted from one generation to the next and thus propagate the unique properties of the holobiont. The microbial symbionts and the host interact in a cooperative way that affects the health of the holobiont within its environment. Beneficial microbiota protects against pathogens, provides essential nutrients, catabolizes complex polysaccharides, renders harmful chemicals inert, and contributes to the performance of the immune system. In humans and animals, the microbiota also plays a role in behavior. The sum of these cooperative interactions characterizes the holobiont as a unique biological entity. Genetic variation in the hologenome can be brought about by changes in either the host genome or the microbial population genomes (microbiome). Evolution by cooperation can occur by amplifying existing microbes, gaining novel microbiota and by acquiring microbial and viral genes. Under environmental stress, the microbiome can change more rapidly and in response to more processes than the host organism alone and thus influences the evolution of the holobiont. Prebiotics, probiotics, synbiotics and phage therapy are discussed as applied aspects of the hologenome concept.

This enticing collection is as devoted to the profound power of figures of speech as any oration of old Hellas. Metaphor reigns as we encounter the identification of our Earth as a Single, integrative organism, a tale told in image and passion. The discoveries and conjectures upon which this grand view rest are here as well. I have enjoyed these two dozen pieces hugely. No family tree of animal life but must somewhere disclose a cousinly infolding. We are compact of life past, and the looped handing down is more complex than the Mendel-Morgan dance of chromosomes and genes. That dance is essential, certainly, but it is the vital editing of an epic and many-rooted work, a book more like the Bible than like one great artists Remembrance of Things Past. We follow a few old shelves of bound DNA, not just a single book. Our major biochemical package for oxidative metabolism was de scribed in a small DNA manual, somehow engulfed to become an or ganelle within a lucky ancient ancestral anaerobe, and passed ever since viii FOREWORD from mother to offspring outside of the chromosome shuffie. The sperm do carry half the compact genetic message of the human DNA, but they are too small to transfer this equally essential symbiotic one that comes down from the mothers, within roomy egg after roomy egg.

Twenty-six essays probe the phenomena of the universe that have shaped and will shape the future of man from the development of multicellular life to twenty possible ways the world could end.

Scientists act within a social context and from a philosophical perspective that is inherently political. Whether they realize it or not, scientists always choose sides. The Dialectical Biologist explores this political nature of scientific inquiry, advancing its argument within the framework of Marxist dialectic. These essays stress the concepts of continual change and codetermination between organism and environment, part and whole, structure and process, science and politics. Throughout, this book questions our accepted definitions and biases, showing the self-reflective nature of scientific activity within society.

Co-publication with Yale University Press (USA). Discussion of the biological diversity of the earth. Demonstrates how the natural systems that surround us play an essential role in protecting our basic life-support systems. Describes the millions of species providing ecosystem services and explains how biological diversity opens the way for new medicines, construction materials and designs, and manufactured goods. Urges us to protect the biological wealth of the earth from destructive human activity. Includes reccommended reading and index. Beattie is director of the Commonwealth Key Centre for Biodiversity and Bioresources at Macquarie University. Turnbull is a research associate at Macquarie. Erlich is Bing Professor of Population Studies at Stanford University.

More whacky, fun facts with everyone's favourite scientist Dr Karl has taken on Santa Claus, atom bombs, 'friendly' dolphins and 'killer' whales, meteors, black holes, string theory and camel's humps. In his 27 mega-selling books, he demolishes myths, tells readers how to spot bogus science and advises readers to be wise, sceptical and to always challenge authority. In his 28th book he continues his crusade to keep the world a rational place by answering vital questions like 'Are white cats deaf?' and 'Will lemon juice make you slimmer?'

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.

In The Logic of Life François Jacob looks at the way our understanding of biology has changed since the sixteenth century. He describes four fundamental turning points in the perception of the structure of living things: the discoveries of the functions of organs, cells, chromosomes and genes, and DNA.

the Astonishing Elephant is an unabashed celebration of these mysterious creatures, whose closest living relatives are the dugong and the hyrax. "they have," Alexander writes, "essential nobility,grace, serenity, sagacity, loyalty and playfulness, a simple goodness, a alack of animosity - unless provoked." While she admits elephants can pose particular dangers to unwary humans (she recounts tales of circus trainers of her acquaintance, some of whom fell in action), they are too often the victims in any interaction with people. the elephant's fortunes have long been declining: where only a few thousand years ago several species roamed the earth, by 1980 the combined wild populations in Africa and Asia numbered fewer than 100,000 individuals.

""How many creatures walking on this earth / Have their first being in another form?" the Roman poet Ovid asked two thousand years ago. He could not have known the full extent of the truth: Today, biologists estimate a stunning three-quarters of all animal species on earth undergo some form of metamorphosis. But why do tadpoles transform into frogs, caterpillars into butterflies, elvers into eels, immortal jellyfish from sea sprigs to medusae and back again, growing younger and younger in frigid ocean depths? Why must creatures go through massive destruction and remodeling to become who they are? Tracing a path from Aristotle--who rejected the possibility of metamorphosis--to Darwin to today, historian of science Oren Harman explores that central mystery. Metamorphosis, however, isn't just a biological puzzle: It takes us to the very heart of questions of being and identity, whatever kind of change we may undergo. Metamorphosis is a new classic of natural history: a book that, by unveiling a mystery of nature, causes us to relearn ourselves"--Publisher's description.

Lynn Margulis, one of the most original and perceptive scientific thinkers of our time, and the writer Dorion Sagan here present a selection from their many essays published in the last decade and a half. This collection includes an extraordinary memoir of Margulis' encounter with J. Robert Oppenheimer as well as provocative ideas on Gaia theory, symbiosis, individuality, and the way scientific research is conducted today.

An all-inclusive catalogue of the world's living diversity, Five Kingdoms defines and describes the major divisions, or phyla, of nature's five great kingdoms - bacteria, protoctists, animals, fungi, and plants - using a modern classification scheme that is consistent with both the fossil record and molecular data. Generously illustrated and remarkably easy to follow, it not only allows readers to sample the full range of life forms inhabiting our planet but to familiarize themselves with the taxonomic theories by which all organisms' origins and distinctive characteristics are traced and classified.

Gold, gold, gold for Australia's mega-selling scientist's 27th book... 'Nullius in verba', the Royal Society's motto, roughly translated, means 'take nobody's word for it'. Why not do the experiment for yourself and see the reality of nature. Don't trust authority - trust nature.Does cranberry juice cure urinary tract infections? Is the hookah really a safer way to smoke? Will the Large Hadron Collider destroy the Earth and the Universe? Is the purpose of the peacock's tail to attract females? And in the unlikely event of a plane crash, are some seats safer than others?the human hand has 27 bones; Uranus has 27 moons; 27 is a perfect cube, being 3 x 3 x 3; and in this, Dr Karl's 27th book, he takes us on another exploration of the dazzling world of science.

In the next book in Dr Karl's mega-selling science series, Australia's favourite scientist answers more curly questions about life, the universe and everything; questions such as Are virgin births possible? (they are) Will a black hole suck you in? (it won't) Is the most radioactive device in our homes the microwave? (it's not, it's the smoke detector)No-one conveys the excitement and wonder of science quite like Dr Karl and this, his twenty-fifth book, takes us on another thoroughly entertaining exploration of the world around us. If you like your science fun and unpredictable, don't miss this new addition to the Dr Karl library.

In this, his 45th book, Dr Karl goes full kolour, with brilliant and funny illustrations to match his dress sense. So take a technikolour trip through science with the intrepid Dr Karl, Australia's favourite science guru. Q: HOW MANY DR KARL BOOKS ARE THERE IN THE UNIVERSE? A: MORE THAN A MILLION! Dr Karl is on a mission to track down Awe and Wonder in the Universe. Why do wombats poo cubes? What nearly destroyed humanity on Halloween 2015? How do you use an incinerating toilet? Find out why we've sent a spacecraft with Dr Karl's name on it to kiss the Sun, whether cannibalism is nutritious, and the answer to the Biggeset Question of All - why does spaghetti always break into three pieces? Plus a whole lot more. So strap in and get ready for a random ride through the Universe. Who knows where you'll end up!

One of The New York Times Critics' Picks of the Year From acclaimed psychoanalyst Adam Phillips, a meditation on what we must give up to feel more alive. To give up or not to give up? The question can feel inescapable but the answer is never simple. Giving up our supposed vices is one thing; giving up on life itself is quite another. One form of self-sacrifice feels positive, something to admire and aspire to, while the other is profoundly unsettling, if not actively undesirable. There are always, it turns out, both good and bad sacrifices, but it is not always clear beforehand which is which. We give something up because we believe we can no longer go on as we are. In this sense, giving up is a critical moment—an attempt to make a different future. In On Giving Up , the acclaimed psychoanalyst Adam Phillips illuminates both the gaps and the connections between the many ways of giving up and helps us to address the central question: What must we give up in order to feel more alive?