Followed by an assassin and her poisonous snakes, ten-year-old twins Wally and Cheyenne Shluffmuffin try to get from their Ohio home to the FBI training facility in Quantico, Virginia, to get help in freeing human hostages from the onts.

While trying to convince the FBI that giant ants are kidnapping and enslaving the citizens of Cincinnatti, twins Wally and Cheyenne Shluffmuffin, with the help of their vampire father, escape the clutches of the enormous ghouls who want to adopt--and eat--them.