The discovery of how opiates such as morphine and heroin relieve pain and produce euphoria is one of the most dramatic tales of modern science. It begins in 1971 when, at the height of the undeclared war in Vietnam, Richard Nixon officially announced a war on drugs. Heroin addiction--no longer confined to urban ghettos--was causing bad public relations for the White House. The specter of young American soldiers demoralized, drugged, and committing atrocities was not the image President Nixon wished to convey as he argued for further bombings of North Vietnam. In this book Solomon Snyder describes the political maneuverings and scientific sleuthing that led him and Candace Pert, then a graduate student in his lab, to a critical breakthrough in the effort to understand addiction. Their discovery--the so-called opiate receptor--is a structure on the surface of certain nerve cells that attracts opiates. Heroin or morphine molecules fit into opiate receptors much as a key fits into the ignition switch of a car--thus turning on the engine of the cell. Snyder and his students were able to show that nerve cells which possess opiate receptors are found in precisely those parts of the brain that control emotion and pain. Dr. Snyder describes the friendly yet intense competition from other researchers to expand upon this initial discovery. From the work of two Scottish investigators, Hans Kosterlitz and John Hughes, neuroscientists now know not only where opiate receptors are found in the brain but also why they are there: to serve as binding sites for an opiate-like substance produced by the brain itself--the brain's own morphine. This substance, called enkephalin, regulates pain, mood, and a host of other physiological functions. From this very human chronicle of scientific battles in the ongoing war against pain and addiction, we gain an appreciation of the extraordinary intellectual processes of an eminent scientist. But Dr. Snyder's story of scientific brainstorming also affords us rare glimpses into the fruitful, sometimes frustrating, relationships among scientists which enrich and complicate creative work. We are reminded of the delicate political alliances that are forged at every level of organization, from the lab bench to the Oval Office, as the scientific community attempts to fit its needs to those of the larger society.

Gossip is no trivial matter; despite its reputation, Epstein argues, it is an eternal and necessary human enterprise. Proving that he himself is a master of the art, Epstein serves up delightful mini-biographies of the Great Gossips of the Western World, along with many choice bits from his own experience. He also makes a powerful case that gossip has morphed from its old-fashioned best--clever, mocking, a great private pleasure--to a corrosive new-school version, thanks to the reach of the mass media and the Internet. Written in his trademark erudite and witty style, Gossip captures the complexity of this immensely entertaining subject.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

The New York Times ’s James Glanz has called Steven Weinberg “perhaps the world’s most authoritative proponent of the idea that physics is hurtling toward a ‘final theory,’ a complete explanation of nature’s particles and forces that will endure as the bedrock of all science forevermore. He is also a powerful writer of prose that can illuminate—and sting... He recently received the Lewis Thomas Prize, awarded to the researcher who best embodies ‘the scientist as poet.’” Both the brilliant scientist and the provocative writer are fully present in this book as Weinberg pursues his principal passions, theoretical physics and a deeper understanding of the culture, philosophy, history, and politics of science.Each of these essays, which span fifteen years, struggles in one way or another with the necessity of facing up to the discovery that the laws of nature are impersonal, with no hint of a special status for human beings. Defending the spirit of science against its cultural adversaries, these essays express a viewpoint that is reductionist, realist, and devoutly secular. Each is preceded by a new introduction that explains its provenance and, if necessary, brings it up to date. Together, they afford the general reader the unique pleasure of experiencing the superb sense, understanding, and knowledge of one of the most interesting and forceful scientific minds of our era.

In More Things in Heaven and Earth, Levy argues the fundamental unity of the arts and the sciences, pointing out the poetry that is in astronomy and the scientific references to the night sky found in many of the great poets. He illustrates his arguments with spectacular colour photographs of comets and eclipses and also with extensive quotation of and commentary on Chaucer, Shakespeare, Milton, Donne, Keats, Tennyson, Hopkins and Frost. For him the collision of the comet bearing his name with the planet Jupiter, the greatest cataclysm in the history of astronomy, is an opportunity to get a whole new generation excited about our universe in a way that has not been possible since the 1969 Moon landing.

"Leviathan and the Air-Pump examines the conflicts over the value and propriety of experimental methods between two major seventeenth-century thinkers: Thomas Hobbes, author of the political treatise Leviathan and vehement critic of systematic experimentation in natural philosophy, and Robert Boyle, mechanical philosopher and owner of the newly invented air-pump. The issues at stake in their disputes ranged from the physical integrity of the air-pump to the intellectual integrity of the knowledge it might yield. Both Boyle and Hobbes were looking for ways of establishing knowledge that did not decay into ad hominem attacks and political division. Boyle proposed the experiment as cure. He argued that facts should be manufactured by machines like the air-pump so that gentlemen could witness the experiments and produce knowledge that everyone agreed on. Hobbes, by contrast, looked for natural law and viewed experiments as the artificial, unreliable products of an exclusive guild.The new approaches taken in Leviathan and the Air-Pump have been enormously influential on historical studies of science. Shapin and Schaffer found a moment of scientific revolution and showed how key scientific givens--facts, interpretations, experiment, truth--were fundamental to a new political order. Shapin and Schaffer were also innovative in their ethnographic approach. Attempting to understand the work habits, rituals, and social structures of a remote, unfamiliar group, they argued that politics were tied up in what scientists did, rather than what they said. Steven Shapin and Simon Schaffer use the confrontation between Hobbes and Boyle as a way of understanding what was at stake in the early history of scientific experimentation. They describe the protagonists' divergent views of natural knowledge, and situate the Hobbes-Boyle disputes within contemporary debates over the role of intellectuals in public life and the problems of social order and assent in Restoration England. In a new introduction, the authors describe how science and its social context were understood when this book was first published, and how the study of the history of science has changed since then." -- Amazon.com.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

During the sixteenth and seventeenth centuries a radical change occurred in the patterns and framework of European thought. In the wake of Copernican theory and discoveries through the telescope, the notion of an ordered cosmos of "fixed stars" gave way to that of a universe infinite in both time and space-with significant and far-reaching consequences for human thought. Alexandre Koyré brilliantly interprets this revolution in terms of the change that occurred in our conception of the universe and our place in it, and illustrates the primacy of this change in the development of the modern world. "An important contribution to the problem of the transition from the world view characteristic of the medieval centuries to that which rapidly gained acceptance after the seventeenth century." (Philosophical Quarterly) "Koyré has provided the material and has illuminated it with uniformly perceptive and occasionally brilliant commentary.... An important contribution to the study of 17th-century thought." (Thomas S. Kuhn, Science) "A model of scholarliness without pedantry, of clarity without oversimplification." (Arthur Koestler, Encounter) "Surely a work that will be welcomed alike by the scientist, philosopher, and historian of ideas." (Philosophy and Phenomenological Research) Alexandre Koyré was a member of the Institute for Advanced Study, Princeton, and professor at the Ecole Pratique des Hautes Etudes in Paris. His books include Discovering Plato and Newtonian Studies.

How is it that nobody--except maybe scientists--sees science for what it is? In this entertaining and provocative book, Lewis Wolpert draws on the entire history of science, from Thales of Miletus to Watson and Crick, from the study of eugenics to the discovery of the double helix. The result is a scientist's view of the culture of science, authoritative and informed and at the same time mercifully accessible to those who find cohabiting with this culture a puzzling experience. Science is arguably the defining feature of our age. For anyone who hopes to understand its nature, this lively and thoughtful book provides the perfect starting point.

Hilary Putnam has been convinced for some time that the present situation in philosophy calls for revitalization and renewal; in this latest book he shows us what shape he would like that renewal to take. Words and Life offers a sweeping account of the sources of several of the central problems of philosophy, past and present, and of why some of those problems are not going to go away As the first four part tides in the volume-"The Return of Aristotle," "The Legacy of Logical Positivism," "The Inheritance of Pragmatism," and "Essays after Wittgenstein"-suggest, many of the essays are concerned with tracing the recent, and the not so recent, history of these problems. The goal is to bring out what is coercive and arbitrary about some of our present ways of posing the problems and what is of continuing interest in certain past approaches to them. Various supposedly timeless philosophical problems appear, on closer inspection, to change with altered historical circumstances, while there turns out to be much of permanent value in Aristotle's, Peirce's, Dewey's, and Reichenbach's work on some of the problems that continue to exercise us. A unifying theme of the volume as a whole is that reductionism, scientism, and old-style disenchanted naturalism tend to be obstacles to philosophical progress. The titles of the final three parts of the volume-Truth and Reference," "Mind and Language," and "The Diversity of the Sciences-indicate that the sweep of the problems considered here comprehends all the fundamental areas of contemporary analytic philosophy Rich in detail, the book is also grand in scope, allowing us to trace the ongoing intellectual evolution of one of the most significant philosophers of the century.

During the Soviet years, Russian science was touted as one of the greatest successes of the regime. Russian science was considered to be equal, if not superior, to that of the wealthy western nations. The Perversion of Knowledge, a history of Soviet science that focuses on its control by the KGB and the Communist Party, reveals the dark side of this glittering achievement. Based on the author's firsthand experience as a Soviet scientist, and drawing on extensive Russian language sources not easily available to the Western reader, the book includes shocking new information on biomedical experimentation on humans as well as an examination of the pernicious effects of Trofim Lysenko's pseudo-biology. Also included are many poignant case histories of those who collaborated and those who managed to resist, focusing on the moral choices and consequences. The text is accompanied by the author's own translations of key archival materials, making this work an essential resource for all those with a serious interest in Russian history.

"Science is often thought of as a methodical but dull activity. But the finest science, the breakthroughs most admired and respected by scientists themselves, is characterized by elegance." "What does elegance mean in the context of science? Economy is a considerable part of it; creativity too. Sometimes, a suggested solution is so simple and neat that it elicits an exclamation of wonder from the observer. The greatest science, whether primarily theoretical or experimental, reflects a creative imagination." "In this book, the distinguished physiologist and writer Ian Glynn explores some of the finest examples of elegance in science: the delightful simplicity of the laws discovered by Kepler and Newton in the motion of the planets; Galileo's experiments with an inclined plane; the remarkable work of Thomas Young on light; dazzling insights into the counterintuitive workings of our perception demonstrated by Richard Gregory and Vilayanur Ramachandran; and the several breakthroughs that led to Crick and Watson's unravelling of the structure and function of DNA. The result is a fascinating tour through some of the most important episodes in the history of science."--BOOK JACKET.

This provocative new collection of essays by a Pulitzer Prize winner deals with the challenging themes of discovery and surprise in history. Cleopatra's Nose is not a miscellany but rather a selection of recent essays illustrating specific subjects that have preoccupied Boorstin for several decades. Tantalizing themes all: How sometimes discovery only increases our ignorance. What were the specific historical opportunities in the New World? How has the fourth kingdom - the kingdom of machines - contradicted Darwinian expectations, contributed to a confusion of statistics, created the need for the unnecessary, and highlighted the paradoxes of science and the politics of common sense? In a "personal postscript," Boorstin gives us a memorable and affectionate portrait of his father and optimistically celebrates the United States as the Land of the Unexpected.

"This book contains the text of Thomas Kuhn's unfinished book, The Plurality of Worlds: An Evolutionary Theory of Scientific Development, which Kuhn himself described as "a return to the central claims of The Structure of Scientific Revolutions, and the problems that it raised but did not resolve." The Plurality of Worlds is preceded by two related texts that Kuhn publicly delivered but never published in English: his paper "Scientific Knowledge as a Historical Product" and his Shearman Memorial Lectures, "The Presence of Past Science." The book opens with an introduction by the editor that describes the origins and structure of The Plurality of Worlds, and sheds light on its central philosophical problems. Kuhn's aims in his last writings are bold. He sets out to develop an empirically grounded theory of meaning that would allow him to make sense of both the possibility of historical understanding and the inevitability of incommensurability between past and present science. Moreover, he intends to show that incommensurability is fully compatible with a robust notion of a real world that science investigates, with the rationality of scientific belief change, and with the idea that scientific development is progressive. This is a must-read follow-up to The Structure of Scientific Revolutions, one of the most important books of the twentieth century"--

This book explores changing American views of race mixing in the twentieth century, showing how new scientific ideas transformed accepted notions of race and how those ideas played out on college campuses in the 1960s. In the 1930s, it was not unusual for medical experts to caution against miscegenation, or race mixing, espousing the common opinion that it would produce biologically dysfunctional offspring. By the 1960s the scientific community roundly refuted this theory. The author traces this revolutionary shift in scientific thought, explaining how developments in modern population biology, genetics, and anthropology proved that opposition to race mixing was a social prejudice with no justification in scientific knowledge. In the 1960s, this new knowledge helped to change attitudes towards race and discrimination, especially among college students. Their embrace of social integration caused tension on campuses across the country. Students rebelled against administrative interference in their private lives, and university regulations against interracial dating became a flashpoint in the campus revolts that revolutionized American educational institutions. The author's provocative study is a personal one, featuring interviews with mixed-race couples and stories from the author's student years at the University of Pittsburgh. As such, this book offers a unique perspective on how contentious debates taking place on college campuses reflected shifts in race relations in the larger society. -- from Back Cover

What’s the most useful thing you could know about your own life? In this era-defining book, developed from her groundbreaking Radio 4 essay series, Naomi Alderman turns her boundless curiosity and incisive thinking to a question that affects us all: how do we understand, and navigate, the epoch we’re living through? She calls this epoch the Information Crisis. The internet has flooded us with more knowledge, opinions, ideas, opportunities, as well as verbal attacks and misinformation, than ever before. It lets us learn more quickly and also spread falsehood more quickly, it brings us together and also divides us in new ways, it is now the lens through which we perceive and understand the world. There is no going back. But we have been here before. In fact, this is humanity’s third information crisis. The first, the invention of writing 5,000 years ago, and the second, the invention of the printing press 600 years ago, drastically reshaped our perceptions, interactions and mental landscapes in ways that feel acutely familiar. Overwhelmed by information, people become afraid and angry, unsettled and distressed, as well as more knowledgeable, educated and curious. By looking at those previous information crises, both the turmoil and the advances, Alderman asks what we can learn from the past to better understand our present, and prepare for our future. Drawing on the work of philosophers and historians, Don’t Burn Anyone at the Stake Today explores how new technology opens up new ways of being and helps us chart a way forward (once again), through the turbulent seas of information overload.[Bokinfo]

Once upon a time 'The Scientific Revolution of the 17th century' was an innovative concept that inspired a stimulating narrative of how modern science came into the world. Half a century later, what we now know as 'the master narrative' serves rather as a strait-jacket - so often events and contexts just fail to fit in. No attempt has been made so far to replace the master narrative. H. Floris Cohen now comes up with precisely such a replacement. Key to his path-breaking analysis-cum-narrative is a vision of the Scientific Revolution as made up of six distinct yet narrowly interconnected, revolutionary transformations, each of some twenty-five to thirty years' duration. This vision enables him to explain how modern science could come about in Europe rather than in Greece, China, or the Islamic world. It also enables him to explain how half-way into the 17th century a vast crisis of legitimacy could arise and, in the end, be overcome --

Known to physicists as the "miracle year," 1932 saw the discovery of the neutron and the first artificially induced nuclear transmutation. However, while physicists celebrated these momentous discoveries--which presaged the era of big science and nuclearbombs--Europe was moving inexorably toward totalitarianism and war. In April of that year, about forty of the world's leading physicists--including Werner Heisenberg, Lise Meitner, and Paul Dirac--came to Niels Bohr's Copenhagen Institute for their annual informal meeting about the frontiers of physics. Physicist Gino Segráe brings to life this historic gathering, which ended with a humorous skit based on Goethe's Faust--little knowing the Faustian bargains they would face in the near future. Capturing the interplay between the great scientists as well as the discoveries they discussed and debated, Segráe evokes the moment when physics--and the world--was about to lose its innocence.--From publisher description.

What is good science? What goal--if any--is the proper end of scientific activity? Is there a legitimating authority that scientists mayclaim? Howserious athreat are the anti-science movements? These questions have long been debated but, as Gerald Holton points out, every era must offer its own responses. This book examines these questions not in the abstract but shows their historic roots and the answers emerging from the scientific and political controversies of this century. Employing the case-study method and the concept of scientific thematathat he has pioneered, Holton displays the broad scope of his insight into the workings of science: from the influence of Ernst Mach on twentiethcentury physicists, biologists, psychologists, and other thinkers to the rhetorical strategies used in the work of Albert Einstein, Niels Bohr, and others; from the bickering between Thomas Jefferson and the U.S. Congress over the proper form of federal sponsorship of scientific research to philosophical debates since Oswald Spengier over whether our scientific knowledge will ever be "complete." In a masterful final chapter, Holton scrutinizes the "anti-science phenomenon," the increasingly common opposition to science as practiced today. He approaches this contentious issue by examining the world views and political ambitions of the proponents of science as well as those of its opponents-the critics of "establishment science" (including even those who fear that science threatens to overwhelm the individual in the postmodern world) and the adherents of "alternative science" (Creationists, New Age "healers," astrologers). Through it all runs the thread of the author's deep historical knowledge and his humanistic understanding of science in modern culture. Science and Anti-Science will be of great interest not only to scientists and scholars in the field of science studies but also to educators, policymalcers, and all those who wish to gain a fuller understanding of challenges to and doubts about the role of science in our lives today.