For twelve months beginning in January 2000, celebrated essayist and research physician Gerald Weissmann carefully documented the modern age of enlightenment, charting its scientific marvels and new plagues. Now, this illuminating diary takes us on a literary exploration of laboratories and beyond to see the impact on human life and culture of headliners such as RU 486, AIDS drugs, and other current developments, including the controversial use of stem cells. Whether calling on Ralph Waldo Emerson to explain Craig Venter's drive to unravel the genome or tracing the effect of Rachel Carson's legacy on the spread of malaria around the world, Weissmann's lively chronicle captures the greatest genetic revolution of all time.

For many years the term fin de siècle has been used to imply a state of decadence which was thought to have pervaded 'civilised' European society in the years around 1900. This volume of essays, which draw on a very wide range of disciplines, argues that the period was in fact one of dramatic change, essentially positive and forward-looking in character. This was the period of the rise of the giant corporation, of mass production and mass consumption, and of the development of the generation and distribution of electrical energy. Novel social features such as mass politics, mass media, and mass sport involved the body of ordinary people and in the arts, complex reactions to contemporary social reality were aroused and expressed. This was also the period which gave birth to the study of quantum mechanics, relativity physics, mental processes and genetics. This volume forms part of a sequence of collections of essays which began with The Enlightenment in National Context (1981) and has continued with Romanticism in National Context (1988). They bring together comparative, national and interdisciplinary approaches to the history of great movements in the development of human thought and actions.

Hermann Joseph Muller (1890-1967) was a member of the early genetics group at Columbia University that developed the chromosome theory of inheritance. T. H. Morgan received the Nobel Prize in Medicine and Physiology for this work in 1934, and Muller, his student, received the Nobel Prize in 1946 for his discovery of radiation-induced mutation. Muller's writings extended beyond contributions to technical journals. He was an active critic of social abuse of science; he advocated eugenic programs based on free choice; and he played a major role in the reform of high school biology. Muller's social views were published in magazines and journals which are accessible to scholars more than to the lay reader or student. They have been collected here to show how extensively he thought our lives are affected by radiation, evolution, modern medicine, and gene theory. He attempted to alert humanity to the dangers of neglect and abuse of their genetic heritage. He also used humanistic values to urge mankind to improve itself, to foster cooperativeness, to increase health and intelligence, and to adopt and evolutionary outlook. A companion collection of essays, The Modern Concept of Nature: Essays on Theoretical Biology by H. J. Muller, also published by State University of New York Press, deals with Muller's scientific contributions to genetics and evolution. It was Muller who developed the relation between genes and mutation; his views on the primacy of the gene in biology are reflected today in the similar primacy of nucleic acids as the basis of life. For students of the history of ideas, a collection of these essays would illustrate how genetic thinking prepared the world view for molecular biologists. The relation of science to values is often neglected because of the inaccessibility of the written contributions of famous scientists. To read Muller's major essays in these two areas is an important way to evaluate a scientist's career, his maturation of ideas, and his developing application of science to society.

This is a gothic noir novel that explores questions about fate, identity, and genetics in the guide of a gripping psychological thriller.

Well aware of Jews having once been the victims of Nazi eugenics policies, many Jews today have an ambivalent attitude toward new genetics and are understandably wary of genetic forms of identity and intervention. At the same time, the Jewish tradition is strongly committed to medical research designed to prevent or cure diseases. Jews and Genes explores this tension against the backdrop of various important developments in genetics and bioethics—new advances in stem cell research; genetic mapping, identity, testing, and intervention; and the role of religion and ethics in shaping public policy. Jews and Genes brings together leaders in their fields, from all walks of Judaism, to explore these most timely and intriguing topics—the intricacies of the genetic code and the wonders of life, along with cutting-edge science and the ethical issues it raises.

Papers on the location and behavior of zeros, including some of Polya's most influential work.The papers in this volume cluster about the following topics: the location of the zeros of polynomials and other analytic functions; the approximation of analytic functions by polynomials in which the location of zero is restricted (these papers represent some of Polya's most influential work); the behavior of the zeros of successive derivatives; the zeros of functions defined by trigonometric integrals; and the signs of derivatives and their analytic character. The volume also includes a paper that is not about zeros but contains a representation theorem for positive polynomials in several variables.

Shares information based on lectures given in 1993 about the traffic in scientific research between metaphors and machines, between software and hardware, between language and science, and about the normal process of scientific exchange.

This is the first book to explore the effect of genetic research on the Lemba Judaising community of Southern Africa and the phenomenon of Israelite identity. The science of genetics as relayed by the media is perceived by laymen as being irreproachably objective 'hard science': its disinterested 'scientific' findings appear immensely impressive and may therefore act as a powerful catalyst for change. In this case, an oral tradition cherished by many of the Lemba that they are of Jewish origin appears to be supported by recent DNA testing, which has deeply affected the narrative and religious identity of the group and the way the tribe is perceived in the Western world. International in appeal, this topical text brings together cutting-edge research on the social, cultural and ethical implications of genetics and the study of Judaising movements across the world. This book will be of interest to researchers and students of Jewish history, genetic anthropology, race and ethnicity studies, and religious and cultural studies.

'My mother was the source of my brains and my father the mother of kindness,' said Sandor Rado, a Hungarian analyst whom Freud first embraced but with whom he was later displeased. In Heresy: Sandor Rado and the Psychoanalytic Movement, Paul Roazen and Bluma Swerdloff use interviews with Rado and his family to bring to life one of Freud's foremost followers, who later founded his own institute and psychodynamic orientation, one that focused on motivation rather than instinct. Based on interviews sponsored by the Columbia University Oral History Project, and including Freud's letters to Rado, this is a personal account of Rado and the life events that shaped him and his theories. Rado's life in late nineteenth-century Hungary, the enduring influence of his mother, his meetings with Freud (who made three slips of the tongue during their first encounter), his analysis with Karl Abraham, his affair with Helene Deutsch (she called it a 'companionship of suffering'), and Rank and Ferenczi's downfalls are vividly depicted. Rado's radical departure from Freudian theories of femininity, a reformulation daringly in keeping with today's gender debates, is also included. Rado freed himself from phallocentrism, abandoning the notions of universal castration fear and penis envy. He contended that men and woman are different, which does not mean that women are inferior. He saw women as having a greater emotional capacity based on their biological role as child bearers and nurturers. In 1963, as further evidence of his prescience, Rado prophesied the current crisis in psychotherapy, noting that 'the old-fashioned therapeutic practice will disappear for lack of money.' He anticipated that the influence of biochemical genetics was going to be 'so enormous that it would be bootless to try to outline it.' Dr. Swerdloff uses Rado's predictions and an analysis of the present debate to demonstrate the need to steer psychoanalysis toward a more scientific course.

Dworkin and His Critics provides an in-depth, analytical discussion of Ronald Dworkin's moral, ethical, legal, and political philosophical writings.As the first text to cover such a wide range of Dworkin's thought, it makes a substantial contribution to a number of ongoing academic debates over abortion, euthanasia, the rule of law, distributive justice, group rights, political obligation, and genetics. Underpinning Dworkin 's work are fundamental principles of political morality, discussion of which is a central focus of the book. The 18 contributors include Richard J. Arneson, G. A. Cohen, F. M. Kamm, Will Kymlicka, Philippe van Parijs, Eric Rakowski, Seana Valentine Shiffrin, and Jeremy Waldron.This collection of primarily new essays features substantial replies by Ronald Dworkin and a comprehensive bibliography of his work. Dworkin and His Critics, an interdisciplinary work, is indispensable for students, instructors, and scholars in the fields of philosophy, law, and politics.

Product Description This handbook offers original, critical perspectives on different approaches to the history of biology. This collection is intended to start a new conversation among historians of biology regarding their work, its history, and its future. Historical scholarship does not take place in isolation: As historians create their narratives describing the past, they are in dialogue not only with their sources but with other historians and other narratives. One important task for the historian is to place her narrative in a historiographic lineage. Each author in this collection offers their particular perspective on the historiography of a range of topics from Model Organisms to Eugenics, Molecular Biology to Biotechnology, Women, Race, Scientific Biography, Genetics, Darwin and more. Rather than comprehensive literature reviews, the essays critically reflect upon important historiographic trends, offering pointed appraisals of the field by leading scholars. Other authors will surely have different perspectives, and this is the beauty and challenge of history-making. The Handbook of the Historiography of Biology presents an opportunity to engage with each other about how the history of biology has been and will be written. About the Author Michael R. Dietrich is Professor and Chair of History and Philosophy of Science at the University of Pittsburgh. He studied Philosophy and Biology at Virginia Tech before earning a doctorate in Philosophy at the University of California, San Diego. As a historian and philosopher of twentieth-century biology, his primary interests are in the nature of scientific controversy. In numerous scholarly articles and chapters, he has explored controversies in evolutionary genetics and molecular evolution, as well as controversial figures, such as the émigré geneticist Richard Goldschmidt. He has coedited several books including Rebels, Mavericks, and Heretics in Biology with Oren Harman (2007), The Educated Eye: Visual Culture and Pedagogy in the Life Sciences with Nancy Anderson (2012), Biology Outside the Box: Boundary Crossers and Innovation in the Life Sciences with Oren Harman (2013), and Dreamers, Visionaries and Revolutionaries in the Life Sciences with Oren Harman (2018). He is currently writing a book on genetic drift with Roberta Millstein and Robert Skipper entitled Survival of the Luckiest: Perspectives on the History and Philosophy of Random Drift in Evolutionary Biology, as well as a biography of Richard Goldschmidt. Mark E. Borrello, Associate Professor of History of Science in the Department of Ecology, Evolution and Behavior, and Director of the Program in the History of Science and Technology, at the University of Minnesota, studied history and philosophy of science at Indiana University earning a doctorate in 2002. Before coming to the University of Minnesota, he was a visiting assistant professor at the Lyman Briggs School at Michigan State University. As a historian and philosopher of biology, his primary interests are in the development of evolutionary theory in the late-19th and 20th centuries. In numerous scholarly articles and chapters, he has explored the debate over the levels of selection idea from Darwin to the present. His 2010 book on this topic, Evolutionary Restraints: the Contentious History of Group Selection, was published by the University of Chicago Press. He is currently engaged in an investigation of the nature of individuality in developmental and evolutionary contexts. He has published on this topic with his colleagues Michael Travisano, William Ratcliff and Ford Denison (PNAS 2012). His work has been supported by grants from the National Science Foundation. Oren Harman is the Chair of the Graduate Program in Science, Technology and Society at Bar Ilan University and Senior Research Fellow at the Van Leer Jerusalem Institute, where he hosts the public series "Talking About Science in the 21st Century" and the Science and Creativity Group

**** The third edition (1990) is cited in Brandon-Hill. A text that focuses on the decision-making process which precedes and governs the selection of treatment of various pediatric orthopedic conditions. Each author provides the basic science that relates to the condition under discussion and the scientific basis for treatment decisions. This revised and updated edition is also completely reorganized, adding a second editor and 16 new authors. New chapters deal with orthopedic genetics, history taking and examination of the pediatric patient, syndromes and localized disorders affecting bone, neuromuscular disorders, and fracture treatment, a major portion of pediatric orthopedic practice. Thoroughly illustrated in bandw. Annotation copyright by Book News, Inc., Portland, OR

1. Psychodynamic Psychotherapy with Children: Current Status and Guidelines for Future Research.- 1. Nonbehavioral Child Psychotherapy.- 2. Brief Abstracts of Research Providing Findings on the Factors Affecting the Process and Outcome of Parent and Child Psychotherapy.- 2.1. Psychotherapeutic Treatment of the Maladjusted Child in the Ordinary School.- 2.2. The Outcome of Psychotherapeutic Intervention with Delinquent Boys.- 2.3. Outcome of Child Psychotherapy as a Function of Frequency of Session.- 2.4. Concluding Remarks.- 3. Guidelines in Formulating Nonbehavioral Child Psychotherapy Research.- 3.1. Defining the Conceptual Link between the Characteristics of the Children and Families Being Treated and the Nature of the Therapeutic Process.- 3.2. The Research Design and Hypotheses.- 4. Concluding Remarks.- 5. References.- 2. Cognitive Mediators of the Outcome of Psychotherapy with Children.- 1. Rationale for This Review.- 2. Method Used to Identify Studies.- 3. Theoretical Perspectives on a Linkage between Cognitive Factors and Therapy Outcomes.- 4. Research on Cognitive Capacity as a Mediator of Therapy Effects.- 4.1. The Problem of Age as a Mediator.- 4.2. Mental Age.- 4.3. Piagetian Cognitive Level.- 4.4. Intelligence.- 5. Research on Cognitions as Mediators of Therapy Effects.- 5.1. Causal Attributions.- 5.2. Locus of Control.- 5.3. Control-Related Beliefs.- 6. Research on the Malleability of Child Cognitions.- 7. Research on the Effects of Modifying Child Cognitions.- 8. Summary and Critique of the Evidence.- 9. Recommendations for Future Research.- 10. References.- 3. Improving the Peer Relationships of Rejected Children.- 1. Introduction.- 2. The Characteristics of Peer-Rejected Children.- 2.1. Definition.- 2.2. Correlates.- 2.3. Critical Features.- 2.4. Clinical Implications.- 3. Models of Peer Rejection and Treatment Approaches.- 3.1. Social Skills Deficits Model.- 3.2. Negative Behavior Model.- 3.3. Reputation Model.- 3.4. Integrated Model.- 4. Clinical Issues.- 4.1. Assessing Peer Relations without Sociometrics.- 4.2. Gaining Access to Peer Groups.- 4.3. Developmental Considerations.- 5. Conclusions.- 6. References.- 4. Diversion from the Juvenile Justice System: Research Evidence and a Discussion of Issues.- 1. Background Considerations.- 1.1. The Specific Context of the Adolescent Diversion Project.- 2. Developing the Original Model.- 2.1. Participant Youth.- 2.2. Student Volunteers.- 2.3. Intervention Model.- 2.4. Results.- 2.5. Conclusions from the Phase One Project.- 3. Phase Two of ADP Development.- 3.1. Youths Involved in Phase Two.- 3.2. Project Operation in Phase Two.- 3.3. Results from Phase Two.- 4. Phase Three of ADP Development.- 4.1. Youths Involved in Phase Three.- 4.2. Project Operation in Phase Three.- 4.3. Results from Phase Three.- 5. Phase Four of ADP Development.- 5.1. Youths Involved in Phase Four.- 5.2. Project Operation in Phase Four.- 5.3. Results from Phase Four.- 6. Critical Issues in the Operation of Diversion Programs.- 6.1. Clinical and Administrative Issues.- 7. Concluding Comments.- 8. References.- 5. Parental Child Abduction: The Problem and Possible Solution.- 1. Introduction.- 1.1. Epidemiology of Child Abduction.- 1.2. Effects on the Child.- 1.3. Possible Solutions.- 2. The Florida Project.- 2.1. Procedures.- 2.2. Outcome.- 3. The National Project.- 3.1. Changes in Procedures.- 3.2. Outcome.- 4. Discussion.- 5. References.- 6. Genetic Factors in Childhood Psychopathology: Implications for Clinical Practice.- 1. Introduction.- 1.1. Advance of Genetic Knowledge.- 1.2. Intelligence and Genetics.- 1.3. Mental Retardation.- 2. Personality and Psychopathology.- 2.1. Normal Personality.- 2.2. Genetic Factors in Behavioral Disorders.- 2.3. Child Psychopathology.- 3. Prevention of Mental Illness.- 4. Social and Ethical Problems Raised by the New Genetic Information.- 5. Other Ethical Issues.- 6. Conclusions.- 7. References.- 7. Obesity of Infancy and Early Childhood: A Diagnostic Schema.

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This book deals with a key area of population genetics: the ratio of the sexes in a population, or the allocation of resources to male versus female reproductive function. Samuel Karlin and Sabin Lessard establish the formal theoretical aspects of the evolution of sex ratio within the constraints of genetic mechanisms of sex determination. Their results generalize and unify existing work on the topic, strengthening previous conceptions in some cases and, in other instances, offering new directions of research. There are two main approaches to understanding the causes and effects of sex ratio. One approach focuses on the optimization and adaptive functions of sex allocation, while the other emphasizes the consequences of genetic sex determination mechanisms. In discussing the utility of these two approaches, Professors Karlin and Lessard examine the principal sex-determining mechanisms and facts involved in sex ratio representations, the various genetic and environmental factors that contribute to adaptive sex expression, and the evolution of sex determining systems and controls. From a population genetic perspective, the authors derive evolutionary properties in support of the high incidence of 1:1 sex ratio in natural populations and investigate the conditions that can explain the occurrence of biased sex ratio.