In her long-anticipated fourth collection, The Engineers , Katy Lederer draws on the newfangled languages of reproductive technology, genetic engineering, and global warming to ask the age-old questions: What is "the self"? What is "the other"? And how to reproduce "one's self"? In poems that are both lyrical and playfully autobiographical, Lederer imagines form as a kind of genetics, synthesizing lines out of a rigorous constraint. Things can go wrong. The body--or poem--malfunctions, evacuating crucial parts of itself (miscarriage), or growing too aggressively or quickly (cancer). The body--or poem--attacks or even eats itself (autoimmune dysfunction; autophagy). Written almost entirely in the choral "we," the poems move among the perspectives of the bewildered parent, the unborn child, and the inscrutable God who looks down upon the human world. In a post-Roe landscape, the poems complicate and ultimately refashion our pre-conceived notions of the self--and of life. Radical, uncanny, and stunningly original, The Engineers takes us on a journey to a place we've never been, but that is hauntingly familiar.

Product Description Constance "Connie" Gueyer and Peter Tarker each conduct research in laboratories at Bailey Medical College in New York City. Connie is a 48 year-old virologist (the study of viruses) and working with the Congo River virus. Peter is a 37 year-old geneticist (the study of genes). Virology and genetics are closely connected, so getting each other's opinions at work was the excuse they used to get together. They soon had a relationship going. Connie feels a bit self conscious due to the age difference between them. So she decides to take things slowly. Connie's studies show her the region of the brain that seems to control aging. Since Peter has identified the factor that causes aging, they begin an intense collaboration. The results set the scientific community on its ear! Then Connie sees Peter with his young assistant and believes (wrongly) the worst. In a moment of depression, and while under the influence of some medication, Connie takes a dose of the viral preparation they have been using in tests with lab mice. Shortly afterward though, the mice in those tests began to have serious problems. Review Four Stars: What a wonderful debut novel for Dr. Judith Sulzberger! The characters are well developed and the plot believable. -- Detra Fitch, Huntress Reviews, February 5, 2004 About the Author Judith Sulzberger practiced medicine before turning her attention to writing. For several years, she wrote a health column for the East Hampton Star, currently serves on the Health Science Advisory Board of Columbia University School of Medicine, and is an advisor to the Genome Center at that same university. She spends most of her time in East Hampton with her husband.

"Today's most visionary thinkers reveal the cutting-edge scientific ideas and breakthroughs you must understand. Scientific developments radically change and enlighten our understanding of the world--whether it's advances in technology and medical research or the latest revelations of neuroscience, psychology, physics, economics, anthropology, climatology, or genetics. And yet amid the flood of information today, it's often difficult to recognize the truly revolutionary ideas that will have lasting impact. In the spirit of identifying the most significant new theories and discoveries, John Brockman, publisher of Edge.org ("The world's smartest website"--The Guardian), asked 198 of the finest minds What do you consider the most interesting recent scientific news? What makes it important? Pulitzer Prize-winning author of Guns, Germs, and Steel Jared Diamond on the best way to understand complex problems * author of Seven Brief Lessons on Physics Carlo Rovelli on the mystery of black holes * Harvard psychologist Steven Pinker on the quantification of human progress * TED Talks curator Chris J. Anderson on the growth of the global brain * Harvard cosmologist Lisa Randall on the true measure of breakthrough discoveries * Nobel Prize-winning physicist Frank Wilczek on why the twenty-first century will be shaped by our mastery of the laws of matter * philosopher Rebecca Newberger Goldstein on the underestimation of female genius * music legend Peter Gabriel on tearing down the barriers between imagination and reality * Princeton physicist Freeman Dyson on the surprising ability of small (and cheap) upstarts to compete with billion-dollar projects. Plus Nobel laureate John C. Mather, Sun Microsystems cofounder Bill Joy, Wired founding editor Kevin Kelly, psychologist Alison Gopnik, Genome author Matt Ridley, Harvard geneticist George Church, Why Does the World Exist? author Jim Holt, anthropologist Helen Fisher, and more."--Back cover.

Book by Machlup, Professor Fritz

This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field. The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b 558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.