In 1997, Stanley B. Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate. His struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement. In this book, Prusiner tells the remarkable story of his discovery of prions - infectious proteins that replicate and cause disease but surprisingly contain no genetic material - and reveals how superb and meticulous science is actually practiced with talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner's hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer's, Parkinson's, Lou Gehrig's and other devastating diseases of the brain?

" Here, in his own words, is the story of one of the twentieth century's most creative medical innovators, Dr. Henry Heimlich. The thoracic surgeon is best known for having developed the Heimlich Maneuver, the world's easiest-to-learn and most universally known method to save people from choking to death on food or foreign objects. But many don't know about Dr. Heimlich's other life-saving inventions. He is the inventor of the Heimlich Chest Drain Valve, which saved thousands of lives during the Vietnam War, and the Heimlich MicroTrach, which provides a remarkably efficient way for people to take oxygen. In the present decade, Dr. Heimlich has turned his attention to two devastating illnesses for which medicine has not yet found a cure--cancer and HIV. He describes his research and its promise, as well as the controversy and resistance his new ideas have generated from the medical establishment. Interweaving the author's personal life with riveting stories of his numerous medical breakthroughs, this rich memoir provides insights into the workings of a creative mind and the machinations of the American medical system."

"Phoning Home is a collection of entertaining and thought-provoking essays featuring the author's quirky family, his Jewish heritage, and his New York City upbringing. Jacob M. Appel's recollections and insights, informed and filtered by his advanced degrees in medicine, law, and ethics, not only inspire nostalgic feelings but also offer insight into contemporary medical and ethical issues. At times sardonic and at others self-deprecating, Appel lays bare the most private aspects of his emotional life. "We'd just visited my grandaunt in Miami Beach, the last time we would ever see her. I had my two travel companions, Fat and Thin, securely buckled into the backseat of my mother's foul-tempered Dodge Dart," writes Appel of his family vacation with his two favorite rubber cat toys. Shortly thereafter Fat and Thin were lost forever--beginning, when Appel was just six years old, what he calls his "private apocalypse." Both erudite and full-hearted, Appel recounts storylines ranging from a bout of unrequited love gone awry to the poignant romance of his grandparents. We learn of the crank phone calls he made to his own family, the conspicuous absence of Jell-O at his grandaunt's house, and family secrets long believed buried. The stories capture the author's distinctive voice--a blend of a physician's compassion and an ethicist's constant questioning. "--

The story of a young girl who rescued herself and her family from a Nazi concentration camp, escaped two Communist regimes, and survived to use her firsthand knowledge of pain, hardship, and conflict to provide psychiatric counseling for children

John Marks is something of a national treasure. Warm, funny, passionate, opinionated and occasionally contrary, he is a man whose life for more than 40 years marched in beat with that of the National Health Service. There is scarcely a medical issue or controversy in which John Marks was not involved. Abortion law reform, the doctors' 1970s revolt against the General Medical Council, the foundation of the Royal College of General Practitioners, countless NHS reorganizations, and the bloody battle over NHS pay beds and the pay of junior doctors are just a sample.Then there was the fierce, principled battle over how the medical profession and the public should respond to the terror of a new disease - AIDS. And the great war that was fought over the Conservatives introduction of market forces into the NHS in the late 1980s and early 1990s - an approach to running the NHS that lives on, reincarnated, under the current Labor government.In all of these John Marks played more than a walk-on part. In many he was a principal actor. For anyone wanting fully to understand the BMA's role in all this, this book is thus required reading. But it is much more than just a dry history of times past. It is laced with anecdote, from the horrifying to the hilarious, and on to high politics. John Marks' account of his life and times provides the tale of a warm, human, liberal and occasionally buccaneering man whose passion for life and causes leaves even those who do not always agree with him eager to count him among their friends.