A Nobel Prize–winning cancer biologist, leader of major scientific institutions, and scientific adviser to President Obama reflects on his remarkable career. A PhD candidate in English literature at Harvard University, Harold Varmus discovered he was drawn instead to medicine and eventually found himself at the forefront of cancer research at the University of California, San Francisco. In this “timely memoir of a remarkable career” ( American Scientist ), Varmus considers a life’s work that thus far includes not only the groundbreaking research that won him a Nobel Prize but also six years as the director of the National Institutes of Health; his current position as the president of the Memorial Sloan-Kettering Cancer Center; and his important, continuing work as scientific adviser to President Obama. From this truly unique perspective, Varmus shares his experiences from the trenches of politicized battlegrounds ranging from budget fights to stem cell research, global health to science publishing.

John Marks is something of a national treasure. Warm, funny, passionate, opinionated and occasionally contrary, he is a man whose life for more than 40 years marched in beat with that of the National Health Service. There is scarcely a medical issue or controversy in which John Marks was not involved. Abortion law reform, the doctors' 1970s revolt against the General Medical Council, the foundation of the Royal College of General Practitioners, countless NHS reorganizations, and the bloody battle over NHS pay beds and the pay of junior doctors are just a sample.Then there was the fierce, principled battle over how the medical profession and the public should respond to the terror of a new disease - AIDS. And the great war that was fought over the Conservatives introduction of market forces into the NHS in the late 1980s and early 1990s - an approach to running the NHS that lives on, reincarnated, under the current Labor government.In all of these John Marks played more than a walk-on part. In many he was a principal actor. For anyone wanting fully to understand the BMA's role in all this, this book is thus required reading. But it is much more than just a dry history of times past. It is laced with anecdote, from the horrifying to the hilarious, and on to high politics. John Marks' account of his life and times provides the tale of a warm, human, liberal and occasionally buccaneering man whose passion for life and causes leaves even those who do not always agree with him eager to count him among their friends.