The exclusive, first-hand, behind-the-scenes story of how Pfizer raced to create the first Covid-19 vaccine, told by Pfizer's CEO Dr. Albert Bourla A riveting, fast-paced, inside look at one of the most incredible private sector achievements in history, Moonshot recounts the intensive nine months in 2020 when the scientists at Pfizer, under the visionary leadership of Dr. Albert Bourla, made "the impossible possible"--creating, testing, and manufacturing a safe and effective Covid-19 vaccine that previously would have taken years to develop. Dr. Bourla chronicles how the brilliant, dedicated minds at Pfizer, under the enormous strains of the global pandemic, overcame a series of crises that were compounded by social and political unrest, and reveals the doubts, decisions, obstacles, and failures they encountered. As Dr. Bourla makes clear, Pfizer's success wasn't due to luck; it was because of preparation driven by four simple values--Courage, Excellence, Equity, and Joy. Moonshot is a story of leadership under the most unprecedented circumstances--how Dr. Bourla, a Greek immigrant, a child of Holocaust survivors, and a veterinarian, became the head of one of the world's largest corporations and initiated a dramatic transformation of the organization just before a global health crisis would serve to test the organization, its scientists and its leader, like never before. Moonshot describes best practices that can be used to address the multiple, unprecedented challenges our world faces, reveals Pfizer's implementation of scientific breakthroughs at a record-breaking pace, and offers leadership lessons that can help anyone successfully manage their own seemingly unsolvable problems. As Dr. Bourla explains, "I am sharing the story of our moonshot--the challenges we faced, the lessons we learned, and the core values that allowed us to make it happen--in hopes that it might inspire and inform your own moonshot, whatever that may be."

Although Galileo Galilei lived and died centuries ago, his story is more relevant to our lives than we might realize. Today we face enormous challenges such as climate change that are disregarded or questioned by those who fear that their implications will damage business profitability. Others posit a false dichotomy between religion and science in order to reject scientific evidence whose implications they fear. Galileo confronted this problem 400 years ago. His discoveries were based on observation and experiment. His telescopes revealed previously unknown planets, moons orbiting other planets, and other discoveries that essentially confirmed the Copernican universe that the Church had rejected as heretical because Church theologians insisted on a literal reading of the Bible. Even St. Augustine in the fifth century maintained that the Bible pertained to the realm of faith, not reason. But when Galileo argued essentially the same position before an ecclesiastical court in Rome, he was forbidden from publishing any more books. Livio's life of Galileo shows us how the great thinker made his discoveries about the heavens and also formulated fundamental laws of physics. As an astrophysicist, Livio brings insight into how Galileo reasoned his way to his conclusions, which we know today were accurate. Along with Newton, Galileo remains one of the two great figures at the dawn of the scientific revolution. He insisted on reaching the widest audience possible, publishing his work in Italian rather than Latin as had been the case until his time, when vernacular languages were rapidly replacing Latin throughout Europe. Galileo believed that every educated person should know science as well as literature. Did Galileo actually say at the end of his trial when he was forced to recant his discoveries, as legend has it, And still it moves, referring to the motion of the earth around the sun? Not likely, says Livio, but Galileo nonetheless remains an inspiration to scientists and those who value open-minded inquiry, which as Livio reminds us, remains threatened even today.

From Jeff Pearlman--the New York Times best-selling author of Three Ring Circus--comes the rollicking, outrageous story of the USFL, full of larger-than-life characters and you-can't-make-this-up stories featuring some of the biggest celebrities and buffoons in the game. The United States Football League--known fondly to millions of sports fans as the USFL--did not merely challenge the NFL, but cause its owners and executives to collectively shudder. In its three seasons from 1983-85, it secured multiple television deals, drew millions of fans and launched the careers of legends such as Steve Young, Jim Kelly, Herschel Walker, and Reggie White. But then it died beneath the weight of a particularly egotistical and bombastic team owner--a New York businessman named Donald J. Trump. In Football for a Buck, Jeff Pearlman draws on more than four hundred interviews to unearth all the salty, untold stories of one of the craziest sports entities to have ever captivated America. From 1980s drug excess to airplane brawls and player-coach punch outs, to backroom business deals and some of the most enthralling and revolutionary football ever seen, Pearlman transports readers back in time to this crazy, boozy, audacious, unforgettable era of the game. He shows how fortunes were made and lost on the backs of professional athletes and how, forty years ago, Trump was already a scoundrel and a spoiler. For fans of Terry Pluto's Loose Balls or Jim Bouton's Ball Four and of course Pearlman's own stranger-than-fiction narratives, Football for a Buck is sports as high entertainment--and a cautionary tale of the dangers of ego and excess.

The former dean of the Yale School of Management and Undersecretary of Commerce in the Clinton administration chronicles the 1971 August meeting at Camp David, where President Nixon unilaterally ended the last vestiges of the gold standard--breaking the link between gold and the dollar--transforming the entire global monetary system. Over the course of three days--from August 13 to 15, 1971--at a secret meeting at Camp David, President Richard Nixon and his brain trust changed the course of history. Before that weekend, all national currencies were valued to the U.S. dollar, which was convertible to gold at a fixed rate. That system, established by the Bretton Woods Agreement at the end of World War II, was the foundation of the international monetary system that helped fuel the greatest expansion of middle-class prosperity the world has ever seen. In making his decision, Nixon shocked world leaders, bankers, investors, traders and everyone involved in global finance. Jeffrey E. Garten argues that many of the roots of America's dramatic retrenchment in world affairs began with that momentous event that was an admission that America could no longer afford to uphold the global monetary system. It opened the way for massive market instability and speculation that has plagued the world economy ever since, but at the same time it made possible the gigantic expansion of trade and investment across borders which created our modern era of once unimaginable progress. Based on extensive historical research and interviews with several participants at Camp David, and informed by Garten's own insights from positions in four presidential administrations and on Wall Street, Three Days at Camp David chronicles this critical turning point, analyzes its impact on the American economy and world markets, and explores its ramifications now and for the future.

Over the past few decades there has been a revolution in terms of who controls knowledge and information. This rapid change has imperilled the way we think. Without pausing to consider the cost, the world has rushed to embrace the products and services of four titanic corporations. We shop with Amazon; socialise on Facebook; turn to Apple for entertainment; and rely on Google for information. These firms sell their efficiency and purport to make the world a better place, but what they have done instead is to enable an intoxicating level of daily convenience. As these companies have expanded, marketing themselves as champions of individuality and pluralism, their algorithms have pressed us into conformity and laid waste to privacy. They have produced an unstable and narrow culture of misinformation, and put us on a path to a world without private contemplation, autonomous thought, or solitary introspection - a world without mind. In order to restore our inner lives, we must avoid being co-opted by these gigantic companies, and understand the ideas that underpin their success. Elegantly tracing the intellectual history of computer science - from the Descartes and the enlightenment to Alan Turing to Stuart Brand and the hippie origins of today's Silicon Valley - Foer exposes the dark underpinnings of our most idealistic dreams for technology. The corporate ambitions of Google, Facebook, Apple, and Amazon, he argues, are trampling longstanding liberal values, especially intellectual property and privacy. This is a nascent stage in the total automation and homogenization of social, political, and intellectual life. By reclaiming our private authority over how we intellectually engage with the world, we have the power to stem the tide. At stake is nothing less than who we are, and what we will become. There have been monopolists in the past but today's corporate giants have far more nefarious aims. They're monopolists who want access to every facet of our identities and influence over every corner of our decision-making. Until now few have grasped the sheer scale of the threat. Foer explains not just the looming existential crisis but the imperative of resistance.

"A collection of diverse viewpoints from over 45 thought leaders in the biotechnology industry and their efforts going forward during the COVID-19 pandemic. Biotechnology in the Time of COVID-19 is the opening chapter of a story of how the biotechnology industry rose to battle the COVID-19 virus-told by the leaders of that industry in their own words. The industry has built over more than forty years, an ecosystem of scientists, entrepreneurs, doctors, investors, venture capitalists, analysts, media, and bankers, all committed to advancing global health. In two months, leaders and companies from this ecosystem pivoted from the work they were carrying on pre-COVID-19 to face the virus. Forty-six seven contributors offer historical, personal, and investor perspectives, views from inside the biotech companies, broad lessons, leadership, and a look to the future. COVID-19 was a crisis anticipated by many, but one for which we were inadequately prepared. That has led to an unnecessary catastrophe. Now is the time to shine a light on those who bring hope that we will push back the virus with science and medicine. This book is a collection of the voices from the front of that fight. All share the commitment to fight and the conviction that science and medicine will prevail. The editor royalties and a portion of publisher revenues will be donated to two nonprofits focused on rare disease research: Global Genes (globalgenes.org) and The Institute for Life Changing Medicines (lifechangingmedicines.org)"--

From Pulitzer Prize-winning Washington Post reporter Eli Saslow, a powerful portrait of a country grappling with the pandemic, told through voices of people from all across America The Covid-19 pandemic was a world-shattering event, affecting everyone in the nation. From its first ominous stirrings, renowned journalist Eli Saslow began interviewing a cross-section of Americans, capturing their experiences in real time: An exhausted and anguished EMT risking his life in New York City; a grocery store owner feeding his neighborhood for free in locked-down New Orleans; an overwhelmed coroner in Georgia; a Maryland restaurateur forced to close his family business after forty-six years; an Arizona teacher wrestling with her fears and her obligations to her students; rural citizens adamant that the whole thing is a hoax, and retail workers attacked for asking people to wear masks; patients struggling to breathe and doctors desperately trying to save them. Through Saslow's masterful, empathetic interviewing, we are given a kaleidoscopic picture of a people dealing with the unimaginable. These deeply personal accounts make for cathartic reading, as we see Americans at their worst, and at their resilient best.

Provides a detailed analysis of the DICE model (Dynamic Integrated model of Climate and the Economy) as well as an extensive analysis of the model's results. Coping with the challenges of global warming is a daunting task for both scientists and economists, who must understand future changes, and for policy makers, who must ultimately choose policies to balance risks and costs. Managing the Global Commons presents a unique effort to encompass economic, scientific, and policy aspects of this great geophysical experiment. Managing the Global Commons provides a detailed analysis of the DICE model (Dynamic Integrated model of Climate and the Economy) as well as an extensive analysis of the model's results. DICE is the first dynamic model to include a closed-loop system that includes emissions, concentrations, climate change, damages, and emissions controls. The model is useful for estimating the costs and benefits of different paths for slowing climate change and for analyzing the impact of control strategies over time. The analysis contains a number of methodological advances and major findings - most importantly the construction of a small model to encompass the primary components of the climate and economic system within an optimization framework. Also included are new techniques and results concerning the role of uncertainty and the risk premium involved in policies to slow global warming. In addition, the analysis derives a set of uncertain representative scenarios that summarize the large number of potential outcomes into a manageable number to be used within an optimization framework and incorporated into a contingent-commodity framework. Nordhaus examines several different approaches to climate-change policy: no controls, economic optimization, geoengineering, stabilization of emissions and climate, and a ten-year delay in undertaking climate-change policies. Among these, there is a modest advantage of an efficient policy over no controls or a ten-year delay, while the three stabilization options would impose significant net costs. Overall, Nordhaus observes, the analysis reveals that even with major technological breakthroughs and stringent controls, the momentum of past greenhouse gas emissions coupled with great inertia in climate change policy will lead to an inevitable rendezvous with massive climate change.

Economics is sometimes divided into two parts: positive economics and normative economics. The former deals with how the economic problem is solved, while the latter deals with how the economic problem should be solved. The effects of price or rent control on the distribution of income are problems of positive economics. The desirability of these effects on income distribution is a problem of normative economics. Within economics, the major division is between monetary theory and price theory. Monetary theory deals with the level of prices in general, with cyclical and other fluctuations in total output, total employment, and the like. Price theory deals with the allocation of resources among different uses, the price of one item relative to another. Prices do three kinds of things. They transmit information, they provide an incentive to users of resources to be guided by this information, and they provide an incentive to owners of resources to follow this information. Milton Friedman's classic book provides the theoretical underpinning for and understanding of prices. Economics is not concerned solely with economic problems. It is a social science, and is therefore concerned primarily with those economic problems whose solutions involve the cooperation and interaction of different individuals. It is concerned with problems involving a single individual only insofar as the individual's behavior has implications for or effects upon other individuals. "Price Theory" is concerned not with economic problems in the abstract, but with how a particular society solves its economic problems.

An unsparing, incisive, yet ultimately hopeful look at how we can shed the American obsession with self-reliance that has made us less healthy, less secure, and less fulfilled The promise that you can "pull yourself up by your bootstraps" is central to the story of the American Dream. It's the belief that if you work hard and rely on your own resources, you will eventually succeed. However, time and again we have seen how this foundational myth, with its emphasis on individual determination, brittle self-sufficiency, and personal accomplishment, does not help us. Instead, as income inequality rises around us, we are left with shame and self-blame for our condition. Acclaimed journalist Alissa Quart argues that at the heart of our suffering is a do-it-yourself ethos, the misplaced belief in our own independence and the conviction that we must rely on ourselves alone. Looking at a range of delusions and half solutions--from "grit" to the false Horatio Alger story to the rise of GoFundMe--Quart reveals how we have been steered away from robust social programs that would address the root causes of our problems. Meanwhile, the responsibility for survival has been shifted onto the backs of ordinary people, burdening generations with debt instead of providing the social safety net we so desperately need. Insightful, sharply argued, and characterized by Quart's lively writing and deep reporting, and for fans of Evicted and Nickel and Dimed, Bootstrapped is a powerful examination of what ails us at a societal level and a plan for how we can free ourselves from these self-defeating narratives.

Co-publication with Yale University Press (USA). Discussion of the biological diversity of the earth. Demonstrates how the natural systems that surround us play an essential role in protecting our basic life-support systems. Describes the millions of species providing ecosystem services and explains how biological diversity opens the way for new medicines, construction materials and designs, and manufactured goods. Urges us to protect the biological wealth of the earth from destructive human activity. Includes reccommended reading and index. Beattie is director of the Commonwealth Key Centre for Biodiversity and Bioresources at Macquarie University. Turnbull is a research associate at Macquarie. Erlich is Bing Professor of Population Studies at Stanford University.

"Heinz von Foerster was the inventor of second-order cybernetics, which recognizes the investigator as part of the system he is investigating. The Beginning of Heaven and Earth Has No Name provides an accessible, nonmathematical, and comprehensive overview of von Foerster's cybernetic ideas and of the philosophy latent within them. It distills concepts scattered across the lifework of this scientific polymath and influential interdisciplinarian. At the same time, as a book-length interview, it does justice to von Foerster's élan as a speaker and improviser, his skill as a raconteur. Developed from a week-long conversation between the editors and von Foerster near the end of his life, this work playfully engages von Foerster in developing the difference his notion of second-order cybernetics makes for topics ranging from emergence, life, order, and thermodynamics to observation, recursion, cognition, perception, memory, and communication. The book gives an English-speaking audience a new ease of access to the rich thought and generous spirit of this remarkable and protean thinker"--

Passionate, profound and funny, Berman is inspiring people from all walks of life to get off the sidelines and fight the good fight--and win. This unique book--part manifesto from a leader, part humorous activist memoir from a soccer mom--offers a wryly honest, behind-the-scenes, ultimately uplifting look at the state of the planet. For almost 20 years, Tzeporah Berman has been one of our most influential environmentalists. A founder of ForestEthics and PowerUp Canada, she was instrumental in shaping the tactics and concerns of the modern environmental movement. In her early 20s she faced nearly one thousand criminal charges and 6 years in prison for her role organizing blockades in Canada's rainforest. She later transformed her tactics and sat down with CEOs and political leaders to reshape their policies and practices. In her new role at Greenpeace International she is fighting the problem of our time: climate change. This Crazy Time is an impassioned plea for a better world.

Studies the field of biological chemistry as the study of chemical structures and the chemical mechanism of living things.

"Orenstein is such a breezy, funny writer, it's easy to forget she's an important thinker too."--People In this lively, funny memoir, Peggy Orenstein sets out to make a sweater from scratch--shearing, spinning, dyeing wool--and in the process discovers how we find our deepest selves through craft. Orenstein spins a yarn that will appeal to everyone. The COVID pandemic propelled many people to change their lives in ways large and small. Some adopted puppies. Others stress-baked. Peggy Orenstein, a lifelong knitter, went just a little further. To keep herself engaged and cope with a series of seismic shifts in family life, she set out to make a garment from the ground up: learning to shear sheep, spin and dye yarn, then knitting herself a sweater. Orenstein hoped the project would help her process not just wool but her grief over the recent death of her mother and the decline of her dad, the impending departure of her college-bound daughter, and other thorny issues of aging as a woman in a culture that by turns ignores and disdains them. What she didn't expect was a journey into some of the major issues of our time: climate anxiety, racial justice, women's rights, the impact of technology, sustainability, and, ultimately, the meaning of home. With her wry voice, sharp intelligence, and exuberant honesty, Orenstein shares her year-long journey as daughter, wife, mother, writer, and maker--and teaches us all something about creativity and connection.

"With this one compact statement, Jacob Needleman has forced the discussion of both science and religion in our time into a new, more mature and discriminating phase. . . . It is a way station where those who are seriously exploring the transformation of consciousness will have to stop, take thought, and perhaps re-plot their course."--Theodore Roszak "I want to strongly recommend it to every reader seriously interested in our present cultural situation."--Fritjof Capra "Needleman is unique; he is really on to something. . . . A fine book"--Harvey Cox Western science has operated for centuries on the assumption that we can understand the universe without understanding ourselves. We are just now seeking to make the necessary connection between the general laws of nature to those of our own (inner) nature. But the job won't be done with "massive injections of the new consciousness"; we cannot democratize the sacred by cheapening its demands. "My aim in this book therefore" says Needleman, "has not been to speak of the convergence of science and spirituality, but of their separation. As in nature itself, organic unity is a reciprocal relationship between separate but interdependent entities. In human life as well, there can be no real unity except through the awareness of real divisions. One may then hope to experience the magic power of sustained awareness by itself to bring the harmony that we have until now fruitlessly attempted to impose on ourselves and on our endangered civilization." Jacob Needleman is a professor of philosophy at San Francisco State University and the author of many books, including Money and the Meaning of Life , and The American Soul . In addition to his teaching and writing, he serves as a consultant in the fields of psychology, education, medical ethics, philanthropy, and business, and has been featured on Bill Moyers's acclaimed PBS series A World of Ideas .

From trips to the market to lighting entire cities, power is pivotal to the simplest of everyday necessities. Wars are fought over it, the planet is polluted by it, but now its price has become too high. Are we capable of shifting to cleaner, safer, more reliable sources of energy? Fueling the Future gathers the best and brightest minds in the field Ñ thinkers like Jeremy Rifkin, L. Hunter Lovins, and Allison MacFarlane Ñ and uses their collective wisdom to tackle this pressing question from several angles. The experts predict what a world without oil, which is estimated to run out in 50 years, would be like. What new energy alternatives are available? The use of hydrogen and fuel cells is examined, with surprising conclusions. Fresh, efficient prose makes the experts' controversial answers readable and engaging, as well as thought provoking.

Shipped from UK, please allow 10 to 21 business days for arrival. From Apes to Warlords, hardcover, Good, In good to very good condition. Some shelfwear, inscribed to free-end paper.

Our planet Earth has a huge supply of energy deep inside the Earth. This books tells the story of this geothermal power, what it is, what it can do to help us have a cleaner Earth in the future.