The exclusive, first-hand, behind-the-scenes story of how Pfizer raced to create the first Covid-19 vaccine, told by Pfizer's CEO Dr. Albert Bourla A riveting, fast-paced, inside look at one of the most incredible private sector achievements in history, Moonshot recounts the intensive nine months in 2020 when the scientists at Pfizer, under the visionary leadership of Dr. Albert Bourla, made "the impossible possible"--creating, testing, and manufacturing a safe and effective Covid-19 vaccine that previously would have taken years to develop. Dr. Bourla chronicles how the brilliant, dedicated minds at Pfizer, under the enormous strains of the global pandemic, overcame a series of crises that were compounded by social and political unrest, and reveals the doubts, decisions, obstacles, and failures they encountered. As Dr. Bourla makes clear, Pfizer's success wasn't due to luck; it was because of preparation driven by four simple values--Courage, Excellence, Equity, and Joy. Moonshot is a story of leadership under the most unprecedented circumstances--how Dr. Bourla, a Greek immigrant, a child of Holocaust survivors, and a veterinarian, became the head of one of the world's largest corporations and initiated a dramatic transformation of the organization just before a global health crisis would serve to test the organization, its scientists and its leader, like never before. Moonshot describes best practices that can be used to address the multiple, unprecedented challenges our world faces, reveals Pfizer's implementation of scientific breakthroughs at a record-breaking pace, and offers leadership lessons that can help anyone successfully manage their own seemingly unsolvable problems. As Dr. Bourla explains, "I am sharing the story of our moonshot--the challenges we faced, the lessons we learned, and the core values that allowed us to make it happen--in hopes that it might inspire and inform your own moonshot, whatever that may be."

From Jeff Pearlman--the New York Times best-selling author of Three Ring Circus--comes the rollicking, outrageous story of the USFL, full of larger-than-life characters and you-can't-make-this-up stories featuring some of the biggest celebrities and buffoons in the game. The United States Football League--known fondly to millions of sports fans as the USFL--did not merely challenge the NFL, but cause its owners and executives to collectively shudder. In its three seasons from 1983-85, it secured multiple television deals, drew millions of fans and launched the careers of legends such as Steve Young, Jim Kelly, Herschel Walker, and Reggie White. But then it died beneath the weight of a particularly egotistical and bombastic team owner--a New York businessman named Donald J. Trump. In Football for a Buck, Jeff Pearlman draws on more than four hundred interviews to unearth all the salty, untold stories of one of the craziest sports entities to have ever captivated America. From 1980s drug excess to airplane brawls and player-coach punch outs, to backroom business deals and some of the most enthralling and revolutionary football ever seen, Pearlman transports readers back in time to this crazy, boozy, audacious, unforgettable era of the game. He shows how fortunes were made and lost on the backs of professional athletes and how, forty years ago, Trump was already a scoundrel and a spoiler. For fans of Terry Pluto's Loose Balls or Jim Bouton's Ball Four and of course Pearlman's own stranger-than-fiction narratives, Football for a Buck is sports as high entertainment--and a cautionary tale of the dangers of ego and excess.

The former dean of the Yale School of Management and Undersecretary of Commerce in the Clinton administration chronicles the 1971 August meeting at Camp David, where President Nixon unilaterally ended the last vestiges of the gold standard--breaking the link between gold and the dollar--transforming the entire global monetary system. Over the course of three days--from August 13 to 15, 1971--at a secret meeting at Camp David, President Richard Nixon and his brain trust changed the course of history. Before that weekend, all national currencies were valued to the U.S. dollar, which was convertible to gold at a fixed rate. That system, established by the Bretton Woods Agreement at the end of World War II, was the foundation of the international monetary system that helped fuel the greatest expansion of middle-class prosperity the world has ever seen. In making his decision, Nixon shocked world leaders, bankers, investors, traders and everyone involved in global finance. Jeffrey E. Garten argues that many of the roots of America's dramatic retrenchment in world affairs began with that momentous event that was an admission that America could no longer afford to uphold the global monetary system. It opened the way for massive market instability and speculation that has plagued the world economy ever since, but at the same time it made possible the gigantic expansion of trade and investment across borders which created our modern era of once unimaginable progress. Based on extensive historical research and interviews with several participants at Camp David, and informed by Garten's own insights from positions in four presidential administrations and on Wall Street, Three Days at Camp David chronicles this critical turning point, analyzes its impact on the American economy and world markets, and explores its ramifications now and for the future.

Over the past few decades there has been a revolution in terms of who controls knowledge and information. This rapid change has imperilled the way we think. Without pausing to consider the cost, the world has rushed to embrace the products and services of four titanic corporations. We shop with Amazon; socialise on Facebook; turn to Apple for entertainment; and rely on Google for information. These firms sell their efficiency and purport to make the world a better place, but what they have done instead is to enable an intoxicating level of daily convenience. As these companies have expanded, marketing themselves as champions of individuality and pluralism, their algorithms have pressed us into conformity and laid waste to privacy. They have produced an unstable and narrow culture of misinformation, and put us on a path to a world without private contemplation, autonomous thought, or solitary introspection - a world without mind. In order to restore our inner lives, we must avoid being co-opted by these gigantic companies, and understand the ideas that underpin their success. Elegantly tracing the intellectual history of computer science - from the Descartes and the enlightenment to Alan Turing to Stuart Brand and the hippie origins of today's Silicon Valley - Foer exposes the dark underpinnings of our most idealistic dreams for technology. The corporate ambitions of Google, Facebook, Apple, and Amazon, he argues, are trampling longstanding liberal values, especially intellectual property and privacy. This is a nascent stage in the total automation and homogenization of social, political, and intellectual life. By reclaiming our private authority over how we intellectually engage with the world, we have the power to stem the tide. At stake is nothing less than who we are, and what we will become. There have been monopolists in the past but today's corporate giants have far more nefarious aims. They're monopolists who want access to every facet of our identities and influence over every corner of our decision-making. Until now few have grasped the sheer scale of the threat. Foer explains not just the looming existential crisis but the imperative of resistance.

Doing Physics makes concepts of physics easier to grasp by relating them to everyday knowledge. Addressing some of the models and metaphors that physicists use to explain the physical world, Martin H. Krieger describes the conceptual world of physics by means of analogies to economics, anthropology, theater, carpentry, mechanisms such as clockworks, and machine tool design. The interaction of elementary particles or chemical species, for example, can be related to the theory of kinship—who can marry whom is like what can interact with what. Likewise, the description of physical situations in terms of interdependent particles and fields is analogous to the design of a factory with its division of labor among specialists. For the new edition, Krieger has revised the text and added a chapter on the role of mathematics and formal models in physics. Doing Physics will be of special interest to economists, political theorists, anthropologists, and sociologists as well as philosophers of science.

"A collection of diverse viewpoints from over 45 thought leaders in the biotechnology industry and their efforts going forward during the COVID-19 pandemic. Biotechnology in the Time of COVID-19 is the opening chapter of a story of how the biotechnology industry rose to battle the COVID-19 virus-told by the leaders of that industry in their own words. The industry has built over more than forty years, an ecosystem of scientists, entrepreneurs, doctors, investors, venture capitalists, analysts, media, and bankers, all committed to advancing global health. In two months, leaders and companies from this ecosystem pivoted from the work they were carrying on pre-COVID-19 to face the virus. Forty-six seven contributors offer historical, personal, and investor perspectives, views from inside the biotech companies, broad lessons, leadership, and a look to the future. COVID-19 was a crisis anticipated by many, but one for which we were inadequately prepared. That has led to an unnecessary catastrophe. Now is the time to shine a light on those who bring hope that we will push back the virus with science and medicine. This book is a collection of the voices from the front of that fight. All share the commitment to fight and the conviction that science and medicine will prevail. The editor royalties and a portion of publisher revenues will be donated to two nonprofits focused on rare disease research: Global Genes (globalgenes.org) and The Institute for Life Changing Medicines (lifechangingmedicines.org)"--

Provides a detailed analysis of the DICE model (Dynamic Integrated model of Climate and the Economy) as well as an extensive analysis of the model's results. Coping with the challenges of global warming is a daunting task for both scientists and economists, who must understand future changes, and for policy makers, who must ultimately choose policies to balance risks and costs. Managing the Global Commons presents a unique effort to encompass economic, scientific, and policy aspects of this great geophysical experiment. Managing the Global Commons provides a detailed analysis of the DICE model (Dynamic Integrated model of Climate and the Economy) as well as an extensive analysis of the model's results. DICE is the first dynamic model to include a closed-loop system that includes emissions, concentrations, climate change, damages, and emissions controls. The model is useful for estimating the costs and benefits of different paths for slowing climate change and for analyzing the impact of control strategies over time. The analysis contains a number of methodological advances and major findings - most importantly the construction of a small model to encompass the primary components of the climate and economic system within an optimization framework. Also included are new techniques and results concerning the role of uncertainty and the risk premium involved in policies to slow global warming. In addition, the analysis derives a set of uncertain representative scenarios that summarize the large number of potential outcomes into a manageable number to be used within an optimization framework and incorporated into a contingent-commodity framework. Nordhaus examines several different approaches to climate-change policy: no controls, economic optimization, geoengineering, stabilization of emissions and climate, and a ten-year delay in undertaking climate-change policies. Among these, there is a modest advantage of an efficient policy over no controls or a ten-year delay, while the three stabilization options would impose significant net costs. Overall, Nordhaus observes, the analysis reveals that even with major technological breakthroughs and stringent controls, the momentum of past greenhouse gas emissions coupled with great inertia in climate change policy will lead to an inevitable rendezvous with massive climate change.

Economics is sometimes divided into two parts: positive economics and normative economics. The former deals with how the economic problem is solved, while the latter deals with how the economic problem should be solved. The effects of price or rent control on the distribution of income are problems of positive economics. The desirability of these effects on income distribution is a problem of normative economics. Within economics, the major division is between monetary theory and price theory. Monetary theory deals with the level of prices in general, with cyclical and other fluctuations in total output, total employment, and the like. Price theory deals with the allocation of resources among different uses, the price of one item relative to another. Prices do three kinds of things. They transmit information, they provide an incentive to users of resources to be guided by this information, and they provide an incentive to owners of resources to follow this information. Milton Friedman's classic book provides the theoretical underpinning for and understanding of prices. Economics is not concerned solely with economic problems. It is a social science, and is therefore concerned primarily with those economic problems whose solutions involve the cooperation and interaction of different individuals. It is concerned with problems involving a single individual only insofar as the individual's behavior has implications for or effects upon other individuals. "Price Theory" is concerned not with economic problems in the abstract, but with how a particular society solves its economic problems.

An unsparing, incisive, yet ultimately hopeful look at how we can shed the American obsession with self-reliance that has made us less healthy, less secure, and less fulfilled The promise that you can "pull yourself up by your bootstraps" is central to the story of the American Dream. It's the belief that if you work hard and rely on your own resources, you will eventually succeed. However, time and again we have seen how this foundational myth, with its emphasis on individual determination, brittle self-sufficiency, and personal accomplishment, does not help us. Instead, as income inequality rises around us, we are left with shame and self-blame for our condition. Acclaimed journalist Alissa Quart argues that at the heart of our suffering is a do-it-yourself ethos, the misplaced belief in our own independence and the conviction that we must rely on ourselves alone. Looking at a range of delusions and half solutions--from "grit" to the false Horatio Alger story to the rise of GoFundMe--Quart reveals how we have been steered away from robust social programs that would address the root causes of our problems. Meanwhile, the responsibility for survival has been shifted onto the backs of ordinary people, burdening generations with debt instead of providing the social safety net we so desperately need. Insightful, sharply argued, and characterized by Quart's lively writing and deep reporting, and for fans of Evicted and Nickel and Dimed, Bootstrapped is a powerful examination of what ails us at a societal level and a plan for how we can free ourselves from these self-defeating narratives.

Co-publication with Yale University Press (USA). Discussion of the biological diversity of the earth. Demonstrates how the natural systems that surround us play an essential role in protecting our basic life-support systems. Describes the millions of species providing ecosystem services and explains how biological diversity opens the way for new medicines, construction materials and designs, and manufactured goods. Urges us to protect the biological wealth of the earth from destructive human activity. Includes reccommended reading and index. Beattie is director of the Commonwealth Key Centre for Biodiversity and Bioresources at Macquarie University. Turnbull is a research associate at Macquarie. Erlich is Bing Professor of Population Studies at Stanford University.

"Heinz von Foerster was the inventor of second-order cybernetics, which recognizes the investigator as part of the system he is investigating. The Beginning of Heaven and Earth Has No Name provides an accessible, nonmathematical, and comprehensive overview of von Foerster's cybernetic ideas and of the philosophy latent within them. It distills concepts scattered across the lifework of this scientific polymath and influential interdisciplinarian. At the same time, as a book-length interview, it does justice to von Foerster's élan as a speaker and improviser, his skill as a raconteur. Developed from a week-long conversation between the editors and von Foerster near the end of his life, this work playfully engages von Foerster in developing the difference his notion of second-order cybernetics makes for topics ranging from emergence, life, order, and thermodynamics to observation, recursion, cognition, perception, memory, and communication. The book gives an English-speaking audience a new ease of access to the rich thought and generous spirit of this remarkable and protean thinker"--

A protean look at the science establishment-as well as the personalities behind the scenes-in such fields as behavioral psychology, linguistics, and economics.

"Renewable energy expert Mark Diesendorf issues a powerful challenge in this clear and comprehensive guide to the technology and policies we need to adopt to ensure an ecologically sustainable energy future for the planet. Sustainable Energy Solutions for Climate Change brings together the science, technology, economics and policy issues to provide a unique and truly interdisciplinary approach. It details the enormous recent changes in the energy sector and profiles the renewable energy technologies that can transform our fossil-fuelled energy systems into ecologically sustainable ones. The book provides in-depth analysis of: scenarios for transitioning our polluting energy system to one based on the efficient use of renewable energy; sustainable transport and planning for better cities; why nuclear energy is not the answer; the politics and policies of climate change mitigation; myths about wind and solar energy and energy efficiency; what people can do to overcome vested interests and push reluctant governments to take effective action"--

Passionate, profound and funny, Berman is inspiring people from all walks of life to get off the sidelines and fight the good fight--and win. This unique book--part manifesto from a leader, part humorous activist memoir from a soccer mom--offers a wryly honest, behind-the-scenes, ultimately uplifting look at the state of the planet. For almost 20 years, Tzeporah Berman has been one of our most influential environmentalists. A founder of ForestEthics and PowerUp Canada, she was instrumental in shaping the tactics and concerns of the modern environmental movement. In her early 20s she faced nearly one thousand criminal charges and 6 years in prison for her role organizing blockades in Canada's rainforest. She later transformed her tactics and sat down with CEOs and political leaders to reshape their policies and practices. In her new role at Greenpeace International she is fighting the problem of our time: climate change. This Crazy Time is an impassioned plea for a better world.

Studies the field of biological chemistry as the study of chemical structures and the chemical mechanism of living things.

The work that helped to determine Paul Feyerabend's fame and notoriety, Against Method, stemmed from Imre Lakatos's challenge: "In 1970 Imre cornered me at a party. 'Paul,' he said, 'you have such strange ideas. Why don't you write them down? I shall write a reply, we publish the whole thing and I promise you—we shall have a lot of fun.' " Although Lakatos died before he could write his reply, For and Against Method reconstructs his original counter-arguments from lectures and correspondence previously unpublished in English, allowing us to enjoy the "fun" two of this century's most eminent philosophers had, matching their wits and ideas on the subject of the scientific method. For and Against Method opens with an imaginary dialogue between Lakatos and Feyerabend, which Matteo Motterlini has constructed, based on their published works, to synthesize their positions and arguments. Part one presents the transcripts of the last lectures on method that Lakatos delivered. Part two, Feyerabend's response, consists of a previously published essay on anarchism, which began the attack on Lakatos's position that Feyerabend later continued in Against Method. The third and longest section consists of the correspondence Lakatos and Feyerabend exchanged on method and many other issues and ideas, as well as the events of their daily lives, between 1968 and Lakatos's death in 1974. The delight Lakatos and Feyerabend took in philosophical debate, and the relish with which they sparred, come to life again in For and Against Method, making it essential and lively reading for anyone interested in these two fascinating and controversial thinkers and their immense contributions to philosophy of science. "The writings in this volume are of considerable intellectual importance, and will be of great interest to anyone concerned with the development of the philosophical views of Lakatos and Feyerabend, or indeed with the development of philosophy of science in general during this crucial period."—Donald Gillies, British Journal for the Philosophy of Science (on the Italian edition) "A stimulating exchange of letters between two philosophical entertainers."—Tariq Ali, The Independent Imre Lakatos (1922-1974) was professor of logic at the London School of Economics. He was the author of Proofs and Refutations and the two-volume Philosophical Papers . Paul Feyerabend (1924-1994) was educated in Europe and held numerous teaching posts throughout his career. Among his books are Against Method ; Science in a Free Society ; Farewell to Reason ; and Killing Time: The Autobiography of Paul Feyerabend , the last published by the University of Chicago Press.

2014 Reprint of 1959 Edition. Full facsimile of the original edition, not reproduced with Optical Recognition Software. Michael Polanyi (1891-1976) was an eminent theorist across the fields of philosophy, physical chemistry and economics. Elected to the Royal Society and the American Academy of Arts and Sciences, his contributions to research in the social sciences, and his theories on positivism and knowledge, are of critical academic importance. The three lectures included in this comprehensive volume, first published in 1959, argue for Polanyi's principle of 'tacit knowing' as a fundamental component of knowledge. They were intended to accompany Polanyi's earlier work, "Personal Knowledge," and as a tribute to the philosophical and educational work of Lord A. D. Lindsay.

From trips to the market to lighting entire cities, power is pivotal to the simplest of everyday necessities. Wars are fought over it, the planet is polluted by it, but now its price has become too high. Are we capable of shifting to cleaner, safer, more reliable sources of energy? Fueling the Future gathers the best and brightest minds in the field Ñ thinkers like Jeremy Rifkin, L. Hunter Lovins, and Allison MacFarlane Ñ and uses their collective wisdom to tackle this pressing question from several angles. The experts predict what a world without oil, which is estimated to run out in 50 years, would be like. What new energy alternatives are available? The use of hydrogen and fuel cells is examined, with surprising conclusions. Fresh, efficient prose makes the experts' controversial answers readable and engaging, as well as thought provoking.

THE PROSPECT OF IMMORTALITY IN BILINGUAL AMERICAN ENGLISH AND TRADITIONAL CHINESE 永生的期盼美式英文-繁體中文雙語版本 by Robert C.W. Ettinger 羅伯艾丁格著 with a new (2010) foreword by the author 內有新原作者前言(2010年) -- Sinclair T. Wang, Translator 王振祥，翻譯者 -- is available in hardback (ISBN 978-1-934297-00-1) and paperback (ISBN 978-1-934297-01-8) editions. HERE IS MORE INFORMATION ABOUT THE BOOK (ORIGINALLY PUBLISHED IN ENGLISH IN 1964): In the 1960s Ettinger founded the cryonics (cryonic hibernation) movement and authored The Prospect of Immortality. Ettinger sees "discontinuity in history, with mortality and humanity on one side -- on the other immortality and transhumanity." Cryonic hibernation (experimental long-term suspended animation) of humans may provide a "door into summer" unlike any season previously known. Ettinger argues for his belief in "the possibility of limitless life for our generation." 在1960年代艾丁格創始了冰凍人 (冰凍休眠) 運動，並且著作了永生的期盼一書 。 艾丁格洞見了 "歷史上的不連續， 一邊是會死和凡人 -另一邊則是不死和超人。" 人類的冰凍休眠 （實驗性的長期活體休眠） 可能可以提供一道"進入盛夏之門"， 而且是一個不像任何前所熟悉之季節。 愛丁格爲他在 "我們世代中無窮盡生命可能性" 的信念進行了辯解。 KEYWORDS: biostasis; cryonics; death; future medicine; immortality; life extension; personal identity; suspended animation; technological singularity; transhumanism. HERE IS A TABLE OF CONTENTS OF THE BILINGUAL (IMPROVE YOUR ENGLISH AND/OR YOUR CHINESE?) BOOK OF 552 PAGES: ((CONTENTS IN ENGLISH: )) ---Preface by the Translator ● viii ---FOREWORD 2010 BY ROBERT ETTINGER ● xxii ---Preface by Jean Rostand ● 2 ---Preface by Gerald J. Gruman ● 12 ---Chapter I. Frozen Death, Frozen Sleep, and Some Consequences ● 28 ---Chapter II. The Effects of Freezing and Cooling ● 52 ---Chapter III. Repair and Rejuvenation ● 140 ---Chapter IV. Today's Choices ● 184 ---Chapter V. Freezers and Religion ● 220 ---Chapter VI. Freezers and the Law ● 264 ---Chapter VII. The Economics of Immortality ● 302 ---Chapter VIII. The Problem of Identity ● 364 ---Chapter IX. The Uses of Immortality ● 398 ---Chapter X. Manners, Modes, and Morals of Tomorrow ● 428 ---Chapter XI. The Freezer-Centered Society ● 468 ---References ● 497 ((CONTENTS IN CHINESE: )) ---譯者前言 ● ix ---ROBERT ETTINGER 2010年前言 ● xxiii ---Jean Rostand 前言 ● 3 ---Gerald J. Gruman 前言 ● 13 --- 第一章死亡冰凍，睡眠冰凍，以及其一些後果 ● 29 --- 第二章冰凍和冷卻的一些效應 ● 53 --- 第三章修復和回春 ● 141 --- 第四章當今的選擇 ● 185 --- 第五章冰凍主義和宗教 ● 221 --- 第六章冰凍主義和法律 ● 265 --- 第七章永生的經濟學 ● 303 --- 第八章身分上的問題 ● 365 --- 第九章永生的利用 ● 399 --- 第十章明日的態度，模式和道德 ● 429 --- 第十一章以冰凍人為中心的社會 ● 469 --- 參考資料 ● 497