It was the most radical human-breeding experiment in American history, and no one knew how it turned out. The Repository for Germinal Choice–nicknamed the Nobel Prize sperm bank–opened to notorious fanfare in 1980, and for two decades, women flocked to it from all over the country to choose a sperm donor from its roster of Nobel-laureate scientists, mathematical prodigies, successful businessmen, and star athletes. But the bank quietly closed its doors in 1999–its founder dead, its confidential records sealed, and the fate of its children and donors unknown. In early 2001, award-winning columnist David Plotz set out to solve the mystery of the Nobel Prize sperm bank. Plotz wrote an article for Slate inviting readers to contact him–confidentially–if they knew anything about the bank. The next morning, he received an email response, then another, and another–each person desperate to talk about something they had kept hidden for years. Now, in The Genius Factory, Plotz unfolds the full and astonishing story of the Nobel Prize sperm bank and its founder’s radical scheme to change our world. Believing America was facing genetic catastrophe, Robert Graham, an eccentric millionaire, decided he could reverse the decline by artificially inseminating women with the sperm of geniuses. In February 1980, Graham opened the Repository for Germinal Choice and stocked it with the seed of gifted scientists, inventors, and thinkers. Over the next nineteen years, Graham’s “genius factory” produced more than two hundred children. What happened to them? Were they the brilliant offspring that Graham expected? Did any of the “superman” fathers care about the unknown sons and daughters who bore their genes? What were the mothers like? Crisscrossing the country and logging countless hours online, Plotz succeeded in tracking down previously unknown family members–teenage half-brothers who ended up following vastly different paths, mothers who had wondered for years about the identities of the donors they had selected on the basis of code names and brief character profiles, fathers who were proud or ashamed or simply curious about the children who had been created from their sperm samples. The children of the “genius factory” are messengers from the future–a future that is bearing down on us fast. What will families be like when parents routinely “shop” for their kids’ genes? What will children be like when they’re programmed for greatness? In this stunning, eye-opening book, one of our finest young journalists previews America’s coming age of genetic expectations.

This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. This new edition is fully updated with much more molecular, screening and management information. It covers risk analysis and genetic counseling for individuals with a family history of cancer, and also discusses predictive testing and the organization of the cancer genetics service. It aims to provide such details in a practical format for geneticists and clinicians in all disciplines. This book differs from others in the field in that it is a practical handbook for easy reference for a wide clinical audience. There is a large reference list for further details, as well as information about the genes causing mendelian cancer predisposing condition and their mechanism of action.

. . . Mr. Itzkoff places most of the blame for America's alleged intellectual decline on what he sees as an economically and intellectually elite cast of misguided liberals. They have isolated themselves from American society, he says, by their paternalistic treatment of the underclass, by discounting the importance of traditional family values and by failing to raise enough bright children to sustain national competence. The New York Times Book Review Few doubt that the United States has slipped from its longstanding eminence as the world's wealthiest and most productive nation. The problem for the past 30 years has been the diagnosis of both the decline and then the cure. Literally trillions of dollars have been expended in futile programs to stanch the hemorrhaging of our economic wealth, jobs, educational achievement, and cultural elan. Itzkoff argues that we will never stop the fall until we understand our real national dilemma. This is the decline in our national intelligence profile: fewer citizens of high intelligence, educational potential, and economic productivity. These ideas are taboo. Itzkoff, however, insists that these are the facts, and they must be examined. In this book, he lays out the available evidence for our social disintegration and suggests a rational program of policy initiatives that would begin to restore us to what we were as recently as 1955--the great hope of the world.