Joining the ranks of modern myth busters, Dr. Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria. So why does disease exist? Moalem proposes that most common ailments--diabetes, hemochromatosis, cystic fibrosis, sickle cell anemia--came into existence for very good reasons. At some point they helped our ancestors survive some grand challenge to their existence. Examining the evolution of man, Moalem reveals the role genetic and cultural differences have played in the health and well-being of various races, including their susceptibility to disease. With mesmerizing insight, Moalem offers groundbreaking insight into: - How diabetes may be a biproduct of a mechanism that helped humans survive the Ice Age - Why African Americans living in the north might suffer from vitamin D deficiencies, - Why Asians can't drink as much alcohol as Europeans Revelatory, utterly engaging, and timely--Moalem ponders strongN1, the emerging Avian Flu virus--Why Redheads Feel More Pain and Asians Can't Drink will irrevocably change the way we think about our bodies and ourselves.

An eye-opening investigation into the history of diabetes research and treatment by the award-winning journalist and best-selling author of Why We Get Fat • "[Gary] Taubes’s meticulous, science-based work makes him the Bryan Stevenson of nutrition, an early voice in the wilderness for an unorthodox view that is increasingly becoming accepted."—Niel Barsky , The Guardian Before the discovery of insulin, diabetes was treated almost exclusively through diet, from subsistence on meat, to reliance on fats, to repeated fasting and near-starvation regimens. After two centuries of conflicting medical advice, most authorities today believe that those with diabetes can have the same dietary freedom enjoyed by the rest of us, leaving the job of controlling their disease to insulin therapy and other blood-sugar-lowering medications. Rather than embark on “futile” efforts to restrict sugar or carbohydrate intake, people with diabetes can lead a normal life, complete with the occasional ice-cream cake, side of fries, or soda. These guiding principles, however, have been accompanied by an explosive rise in diabetes over the last fifty years, particularly among underserved populations. And the health of those with diabetes is expected to continue to deteriorate inexorably over time, with ever-increasing financial, physical, and psychological burdens. In Rethinking Diabetes, Gary Taubes explores the history underpinning the treatment of diabetes, types 1 and 2, elucidating how decades-old research that is rife with misconceptions has continued to influence the guidance physicians offer—at the expense of their patients’ long-term well-being. The result of Taubes’s work is a reimagining of diabetes care that argues for a recentering of diet—particularly, fewer carbohydrates and more fat—over a reliance on insulin. Taubes argues critically and passionately that doctors and medical researchers should question the established wisdom that may have enabled the current epidemic of diabetes and obesity, and renew their focus on clinical trials to resolve controversies that are now a century in the making.

"Titillating and provocative essays from one of the freshest voices in science today -- Why do testicles hang the way they do? Is there an adaptive function to the female orgasm? What does it feel like to want to kill yourself? Does "free will" really exist? And why is the penis shaped like that anyway? In Why Is the Penis Shaped Like That?, the research psychologist and award-winning columnist Jesse Bering features more than thirty of his most popular essays from Scientific American and Slate, as well as two new pieces, that take readers on a bold and captivating journey through some of the most taboo issues related to evolution and human behavior. Exploring the history of cannibalism, the neurology of people who are sexually attracted to animals, the evolution of human body fluids, the science of homosexuality, and serious questions about life and death, Bering astutely covers a generous expanse of our kaleidoscope of quirks and origins. With his characteristic irreverence and trademark cheekiness, Bering leaves no topic unturned or curiosity unexamined, and he does it all with an audaciously original voice. Whether you are interested in the psychological history behind the many facets of sexual desire or the evolutionary patterns that have dictated our current mystique and phallic physique, Why Is the Penis Shaped Like That? is bound to create lively discussion and debate for years to come"--

The exclusive, first-hand, behind-the-scenes story of how Pfizer raced to create the first Covid-19 vaccine, told by Pfizer's CEO Dr. Albert Bourla A riveting, fast-paced, inside look at one of the most incredible private sector achievements in history, Moonshot recounts the intensive nine months in 2020 when the scientists at Pfizer, under the visionary leadership of Dr. Albert Bourla, made "the impossible possible"--creating, testing, and manufacturing a safe and effective Covid-19 vaccine that previously would have taken years to develop. Dr. Bourla chronicles how the brilliant, dedicated minds at Pfizer, under the enormous strains of the global pandemic, overcame a series of crises that were compounded by social and political unrest, and reveals the doubts, decisions, obstacles, and failures they encountered. As Dr. Bourla makes clear, Pfizer's success wasn't due to luck; it was because of preparation driven by four simple values--Courage, Excellence, Equity, and Joy. Moonshot is a story of leadership under the most unprecedented circumstances--how Dr. Bourla, a Greek immigrant, a child of Holocaust survivors, and a veterinarian, became the head of one of the world's largest corporations and initiated a dramatic transformation of the organization just before a global health crisis would serve to test the organization, its scientists and its leader, like never before. Moonshot describes best practices that can be used to address the multiple, unprecedented challenges our world faces, reveals Pfizer's implementation of scientific breakthroughs at a record-breaking pace, and offers leadership lessons that can help anyone successfully manage their own seemingly unsolvable problems. As Dr. Bourla explains, "I am sharing the story of our moonshot--the challenges we faced, the lessons we learned, and the core values that allowed us to make it happen--in hopes that it might inspire and inform your own moonshot, whatever that may be."

Soul Made Flesh is the remarkable untold story of a dramatic turning point in history, the exciting discovery of how the human brain works. In an unprecedented examination of how the secrets of the brain were revealed in seventeenth-century England, award-winning author Carl Zimmer tells an extraordinary tale that unfurls against a deadly backdrop of civil war, plague, and the Great Fire of London. At the beginning of that turbulent century, no one knew how the brain worked or even what it looked like intact. By the century's close, the science of the brain had taken root, helping to overturn many of the most common misconceptions and dominant philosophies about man, God, and the universe. Presiding over the rise of this new scientific paradigm was the founder of modern neurology, Thomas Willis, a fascinating, sympathetic, even heroic figure who stands at the center of an extraordinary group of scientists and philosophers known as the Oxford circle. Chronicled here in vivid detail are their groundbreaking revelations and often gory experiments that first enshrined the brain as the chemical engine of reason, emotion, and madness, indeed as the very seat of the human soul. Called 'as fine a science essayist as we have' by The New York Times, Zimmer tells the story of this scientific revolution through the lives of a colorful array of alchemists, mystics, utopians, spies, revolutionaries, and kings. He recreates the religious, ethical, and scientific struggles involved in the pioneering autopsies of the brain carried out by Thomas Willis; the discovery of the circulation of blood by William Harvey and his flight from London with his besieged king, Charles I; René Descartes's persecution by Catholics and Protestants alike for his views of the brain and soul; and the experiments and personal dramas of gifted men who forever changed the way science is practiced as they simultaneously upended our view of our human selves and our place in the world. In this distant mirror to our own time of continuing scientific revolution and worldwide social upheaval, Zimmer brings to life the painstaking, innovative discoveries of Willis and his contemporaries, the taproots of the amazing work of today's neuroscientists, who continue to explore the brain, revealing the hidden workings of emotions, memories, and consciousness. Graced with beautiful illustrations by Christopher Wren, Soul Made Flesh conveys a contagious appreciation for the wonder of the brain, its structure, its many marvelous functions, and the implications for human identity, mind, and morality. It is the definitive history of the dawn of a world-changing science and attitude, the age of the brain and modern consciousness.

"Totem and Taboo" is a collection of four essays by Sigmund Freud that were published together in German in 1913. Freud sought to apply his theories of psychoanalysis to the study of anthropology and early human history. The four essays cover a wide range of topics. In "The Horror of Incest", Freud examines the varied and common rules in primitive cultures that limit contact between members of the same family. In "Taboo and Emotional Ambivalence," Freud posits that primitive cultures and their attitudes about magical objects are similar to the behavior of people with neurotic psychological conditions in the modern world. In "Animism, Magic and the Omnipotence of Thought," Freud draws comparisons between the primitive belief in magic and magical animals to obsessive and compulsive disorders. Finally, in "The Return of Totemism in Childhood," Freud, influenced by one of Charles Darwin's theories about the male-dominated arrangement of early human societies, looks for parallels with his own Oedipus complex theory in the structure of primitive cultures. A classic and influential work of early psychoanalysis, "Totem and Taboo" is an important read for students of both psychology and social anthropology.

A vibrant cultural history investigating pandemics and vaccines, by bestselling author and historian Simon Schama Cities and countries engulfed by panic and death, desperate for vaccines but fearful of what inoculation may bring. This is what the world has just gone through with Covid-19. But as Simon Schama shows in his epic history of vulnerable humanity caught between the terror of contagion and the ingenuity of science, it has happened before. Characteristically, Schama's message is delivered through gripping, page-turning stories set in the eighteenth and nineteenth centuries: smallpox strikes London; cholera hits Paris; plague comes to India. Threading through the scenes of terror, suffering and hope - in hospitals and prisons, palaces, and slums - are an unforgettable cast of characters: a philosopher-playwright burning up with smallpox in a country chateau; a vaccinating doctor paying house calls in Halifax; a woman doctor in south India driving her inoculator-carriage through the stricken streets as dead monkeys drop from the trees. But we are also in the labs when great, life-saving breakthroughs happen, in Paris, Hong Kong, and Mumbai. At the heart of it all is an unsung hero: Waldemar Haffkine, a gun-toting Jewish student in Odesa turned microbiologist at the Pasteur Institute, hailed in England as "the saviour of mankind" for vaccinating millions against cholera and bubonic plague in British India while being cold-shouldered by the medical establishment of the Raj. Creator of the world's first mass production line of vaccines in Mumbai, he is tragically brought down in an act of shocking injustice. Foreign Bodies crosses borders between east and west, Asia and Europe, the worlds of rich and poor, politics and science. Its thrilling story carries with it the credo of its author on the interconnectedness of humanity and nature; of the powerful and the people. Ultimately, Schama says, as we face the challenges of our times together, "there are no foreigners, only familiars."

A New York Times Book Review Editors’ Choice Named a Best Book of the Year by Bloomberg (Chosen by Philip Tetlock), Booklist ’s Top 10 Science Books of the Year, and Shortlisted for Physics World ’s Book of the Year A Major Biography of the Nobel Prize–Winning Physicist, Enrico Fermi, a Leading Architect of the Atomic Age Enrico Fermi is unquestionably among the greats of the world’s physicists, the most famous Italian scientist since Galileo. Called “the Pope” by his peers, he was regarded as infallible in his instincts and research. His discoveries changed our world; they led to weapons of mass destruction and conversely to life-saving medical interventions. This unassuming man struggled with issues relevant today, such as the threat of nuclear annihilation and the relationship of science to politics. Fleeing Fascism and anti-Semitism, Fermi became a leading figure in America’s most secret project: building the atomic bomb. An examination of the human dramas that touched Fermi’s life as well as a thrilling history of scientific innovation in the twentieth century, this is the comprehensive biography that Fermi deserves.

From Pulitzer Prize-winning Washington Post reporter Eli Saslow, a powerful portrait of a country grappling with the pandemic, told through voices of people from all across America The Covid-19 pandemic was a world-shattering event, affecting everyone in the nation. From its first ominous stirrings, renowned journalist Eli Saslow began interviewing a cross-section of Americans, capturing their experiences in real time: An exhausted and anguished EMT risking his life in New York City; a grocery store owner feeding his neighborhood for free in locked-down New Orleans; an overwhelmed coroner in Georgia; a Maryland restaurateur forced to close his family business after forty-six years; an Arizona teacher wrestling with her fears and her obligations to her students; rural citizens adamant that the whole thing is a hoax, and retail workers attacked for asking people to wear masks; patients struggling to breathe and doctors desperately trying to save them. Through Saslow's masterful, empathetic interviewing, we are given a kaleidoscopic picture of a people dealing with the unimaginable. These deeply personal accounts make for cathartic reading, as we see Americans at their worst, and at their resilient best.

Essays by Oliver Sacks, Jonathan Miller, Stephen Jay Gould, Daniel J. Kevles, & R.C. Lewontin explore forgotten and neglected aspects of the history of science.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

NOW FEATURING A NEW AFTERWORD, "PANDEMIC ETHICS" From two eminent scholars comes a provocative examination of bioethics and our culture’s obsession with having it all without paying the price. Shockingly, the United States has among the lowest life expectancies and highest infant mortality rates of any high-income nation, yet, as Amy Gutmann and Jonathan D. Moreno show, we spend twice as much per capita on medical care without insuring everyone. A “remarkable, highly readable journey” (Judy Woodruff ) sure to become a classic on bioethics, Everybody Wants to Go to Heaven but Nobody Wants to Die explores the troubling contradictions between expanding medical research and neglecting human rights, from testing anthrax vaccines on children to using brain science for marketing campaigns. Providing “a clear and compassionate presentation” ( Library Journal ) of such complex topics as radical changes in doctor-patient relations, legal controversies over in vitro babies, experiments on humans, unaffordable new drugs, and limited access to hospice care, this urgent and incisive history is “required reading for anyone with a heartbeat” (Andrea Mitchell).

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

The discovery of how opiates such as morphine and heroin relieve pain and produce euphoria is one of the most dramatic tales of modern science. It begins in 1971 when, at the height of the undeclared war in Vietnam, Richard Nixon officially announced a war on drugs. Heroin addiction--no longer confined to urban ghettos--was causing bad public relations for the White House. The specter of young American soldiers demoralized, drugged, and committing atrocities was not the image President Nixon wished to convey as he argued for further bombings of North Vietnam. In this book Solomon Snyder describes the political maneuverings and scientific sleuthing that led him and Candace Pert, then a graduate student in his lab, to a critical breakthrough in the effort to understand addiction. Their discovery--the so-called opiate receptor--is a structure on the surface of certain nerve cells that attracts opiates. Heroin or morphine molecules fit into opiate receptors much as a key fits into the ignition switch of a car--thus turning on the engine of the cell. Snyder and his students were able to show that nerve cells which possess opiate receptors are found in precisely those parts of the brain that control emotion and pain. Dr. Snyder describes the friendly yet intense competition from other researchers to expand upon this initial discovery. From the work of two Scottish investigators, Hans Kosterlitz and John Hughes, neuroscientists now know not only where opiate receptors are found in the brain but also why they are there: to serve as binding sites for an opiate-like substance produced by the brain itself--the brain's own morphine. This substance, called enkephalin, regulates pain, mood, and a host of other physiological functions. From this very human chronicle of scientific battles in the ongoing war against pain and addiction, we gain an appreciation of the extraordinary intellectual processes of an eminent scientist. But Dr. Snyder's story of scientific brainstorming also affords us rare glimpses into the fruitful, sometimes frustrating, relationships among scientists which enrich and complicate creative work. We are reminded of the delicate political alliances that are forged at every level of organization, from the lab bench to the Oval Office, as the scientific community attempts to fit its needs to those of the larger society.

Gossip is no trivial matter; despite its reputation, Epstein argues, it is an eternal and necessary human enterprise. Proving that he himself is a master of the art, Epstein serves up delightful mini-biographies of the Great Gossips of the Western World, along with many choice bits from his own experience. He also makes a powerful case that gossip has morphed from its old-fashioned best--clever, mocking, a great private pleasure--to a corrosive new-school version, thanks to the reach of the mass media and the Internet. Written in his trademark erudite and witty style, Gossip captures the complexity of this immensely entertaining subject.

This book explores changing American views of race mixing in the twentieth century, showing how new scientific ideas transformed accepted notions of race and how those ideas played out on college campuses in the 1960s. In the 1930s, it was not unusual for medical experts to caution against miscegenation, or race mixing, espousing the common opinion that it would produce biologically dysfunctional offspring. By the 1960s the scientific community roundly refuted this theory. The author traces this revolutionary shift in scientific thought, explaining how developments in modern population biology, genetics, and anthropology proved that opposition to race mixing was a social prejudice with no justification in scientific knowledge. In the 1960s, this new knowledge helped to change attitudes towards race and discrimination, especially among college students. Their embrace of social integration caused tension on campuses across the country. Students rebelled against administrative interference in their private lives, and university regulations against interracial dating became a flashpoint in the campus revolts that revolutionized American educational institutions. The author's provocative study is a personal one, featuring interviews with mixed-race couples and stories from the author's student years at the University of Pittsburgh. As such, this book offers a unique perspective on how contentious debates taking place on college campuses reflected shifts in race relations in the larger society. -- from Back Cover

A fascinating exploration of the limits of human knowledge of our planet, its history and culture, and the universe beyond, from the author of The Things that Nobody Knows There are many, many more things that nobody knows. Do animals have a sense of humor? Why do we have five fingers? How long can humans live? What did Jesus do in his youth? Which speech did Lincoln deliver at Gettysburg? Does the appendix have any use? Is there an odd perfect number? In this witty and enlightening follow-up to The Things that Nobody Know s, William Hartston takes us on a guided tour of 501 further gaps in our knowledge of cosmology, mathematics, animal behavior, medical science, music, art, and literature.

""Our Nuclear Future: Facts, Dangers And Opportunities"" is a book written by Edward Teller, a renowned physicist and one of the key figures in the development of the atomic bomb. The book provides a comprehensive overview of the current state of nuclear energy, its potential benefits and risks, and the challenges that lie ahead.Teller explores the history of nuclear energy, from its origins in the Manhattan Project to the present day. He discusses the various uses of nuclear energy, including power generation, medical applications, and military uses, and examines the pros and cons of each.The book also delves into the dangers of nuclear energy, including accidents and the potential for nuclear weapons proliferation. Teller examines the safety measures that are in place to prevent accidents, as well as the challenges that arise from the disposal of nuclear waste.Despite these risks, Teller argues that nuclear energy has the potential to provide a safe, reliable, and sustainable source of power for the future. He explores the various technologies that are being developed to make nuclear energy safer and more efficient, including advanced reactors and fusion energy.""Our Nuclear Future"" is a thought-provoking and informative book that provides a balanced and insightful look at the complex issues surrounding nuclear energy. It is a must-read for anyone interested in the future of energy and the role that nuclear energy will play in it.This scarce antiquarian book is a facsimile reprint of the old original and may contain some imperfections such as library marks and notations. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions, that are true to their original work.

This is the first book to explore the effect of genetic research on the Lemba Judaising community of Southern Africa and the phenomenon of Israelite identity. The science of genetics as relayed by the media is perceived by laymen as being irreproachably objective 'hard science': its disinterested 'scientific' findings appear immensely impressive and may therefore act as a powerful catalyst for change. In this case, an oral tradition cherished by many of the Lemba that they are of Jewish origin appears to be supported by recent DNA testing, which has deeply affected the narrative and religious identity of the group and the way the tribe is perceived in the Western world. International in appeal, this topical text brings together cutting-edge research on the social, cultural and ethical implications of genetics and the study of Judaising movements across the world. This book will be of interest to researchers and students of Jewish history, genetic anthropology, race and ethnicity studies, and religious and cultural studies.

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