"A brilliant and brave investigation by Michael Pollan, author of five New York Times best sellers, into the medical and scientific revolution taking place around psychedelic drugs--and the spellbinding story of his own life-changing psychedelic experiences When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third. Thus began a singular adventure into the experience of various altered states of consciousness, along with a dive deep into both the latest brain science and the thriving underground community of psychedelic therapists. Pollan sifts the historical record to separate the truth about these mysterious drugs from the myths that have surrounded them since the 1960s, when a handful of psychedelic evangelists catalyzed a powerful backlash against what was then a promising field of research. A unique and elegant blend of science, memoir, travel writing, history, and medicine, How to Change Your Mind is a triumph of participatory journalism. By turns dazzling and edifying, it is the gripping account of a journey to an exciting and unexpected new frontier in our understanding of the mind, the self, and our place in the world. The true subject of Pollan's "mental travelogue" is not just psychedelic drugs but also the eternal puzzle of human consciousness and how, in a world that offers us both struggle and beauty, we can do our best to be fully present and find meaning in our lives"--

You will automatically receive a 3 month FREE subscription to Harrison's Online 2.0 with your purchase of the HARRISON textbook. Eminently readable, completely current, and dramatically revised, the new fifteenth edition of Harrison's PRINCIPLES OF INTERNAL MEDICINE raises the bar for internal medicine references. Featuring over 90 completely new chapters, HARRISON'S continues to provide the most authoritative record of internal medicine as practiced by the leading experts in the field. And it gives you the one comprehensive database that covers the full spectrum of issues you need to know NOW - basic science, pathophysiology, presenting clinical signs, diagnosis, and the latest treatment guidelines. * Expanded treatment with more algorithms and diagnostic decision trees * A new feature, Genetic Considerations, describes how new advances affect patient care * Clinical Guidelines now added throughout, provide evidence-based treatment strategies * Alternative Medicine...a detailed chapter covers this emerging field * New Chapter on Late Problems in Patients with Cancer * New guidelines on Adolescent Health Care * The latest in Gene Therapy with a new chapter on Screening, Prevention, and Counseling for Genetic Disorders * New chapter on Infertility and Fertility Control * Neurobiology of Disease highlights numerous advances made during "The disease of the Brain" * Late-breaking treatment information on multiple sclerosis, Parkinson's disease, Alzheimer's and more * A new color atlas of malaria-infected red blood cells

In the winter of 1950, Margaret Sanger, then seventy-one, and who had campaigned for women's right to control their own fertility for five decades, arrived at a Park Avenue apartment building. She had come to meet a visionary scientist with a dubious reputation more than twenty years her junior. His name was Gregory Pincus. In The Birth of the Pill, Jonathan Eig tells the extraordinary story of how, prompted by Sanger, and then funded by the wealthy widow and philanthropist Katharine McCormick, Pincus invented a drug that would stop women ovulating. With the support of John Rock, a charismatic and, crucially, Catholic doctor from Boston, who battled his own church in the effort to win public approval for the controversial new drug, he succeeded. Together, these four determined men and women changed the world. Spanning the years from Sanger's heady Greenwich Village days in the early twentieth century to trial tests in Puerto Rico in the 1950s to the cusp of the sexual revolution in the 1960s, this is a grand story of radical feminism, scientific ingenuity, establishment opposition, and, ultimately, a sea change in social attitudes.

"A compelling defense of hormone replacement therapy, exposing the faulty science behind its fall from prominence and giving women the evidence they need to make informed decisions about their health. Now fully revised and updated. For years, hormone replacement therapy (HRT) was the medically approved way to alleviate menopausal symptoms (ranging from hot flushes to brain fog) and reduce the risk of heart disease, Alzheimer's, and osteoporosis. But when a large study by the Women's Health Initiative (WHI) announced, with national fanfare, that women taking HRT had an increased risk of breast cancer, women were scared off, and the treatment was abandoned. Now, Dr. Bluming, a medical oncologist, and Dr. Tavris, a social psychologist, reveal the true story of the WHI's efforts to distort their data to exaggerate unsupported claims of estrogen's harms. Important updates in this edition include: Evidence that demolishes the WHI's claim that HRT causes breast cancer. A list of the WHI's retractions of their original scare stories. Updated findings on estrogen's benefits on heart, brain, bones, and longevity. A critical review of the alternative products and medications being marketed to treat symptoms of menopause. A sobering and revelatory read, Estrogen Matters sets the record straight on estrogen's benefits, providing a light to guide women through this inevitable phase of life."--Publisher.

"What if you woke up one morning and found you'd acquired another self--a double who was almost you and yet not you at all? What if that double shared many of your preoccupations but, in a twisted, upside-down way, furthered the very causes you'd devoted your life to fighting against? Not long ago, the celebrated activist and public intellectual Naomi Klein had just such an experience--she was confronted with a doppelganger whose views she found abhorrent but whose name and public persona were sufficiently similar to her own that many people got confused about who was who. Destabilized, she lost her bearings, until she began to understand the experience as one manifestation of a strangeness many of us have come to know but struggle to define: AI-generated text is blurring the line between genuine and spurious communication; New Age wellness entrepreneurs turned anti-vaxxers are scrambling familiar political allegiances of left and right; and liberal democracies are teetering on the edge of absurdist authoritarianism, even as the oceans rise. Under such conditions, reality itself seems to have become unmoored. Is there a cure for our moment of collective vertigo? Naomi Klein is one of our most trenchant and influential social critics, an essential analyst of what branding, austerity, and climate profiteering have done to our societies and souls. Here she turns her gaze inward to our psychic landscapes, and outward to the possibilities for building hope amid intersecting economic, medical, and political crises. With the assistance of Sigmund Freud, Jordan Peele, Alfred Hitchcock, and bell hooks, among other accomplices, Klein uses wry humor and a keen sense of the ridiculous to face the strange doubles that haunt us--and that have come to feel as intimate and proximate as a warped reflection in the mirror. Combining comic memoir with chilling reportage and cobweb-clearing analysis, Klein seeks to smash that mirror and chart a path beyond despair. Doppelganger asks: What do we neglect as we polish and perfect our digital reflections? Is it possible to dispose of our doubles and overcome the pathologies of a culture of multiplication? Can we create a politics of collective care and undertake a true reckoning with historical crimes? The result is a revelatory treatment of the way many of us think and feel now--and an intellectual adventure story for our times"--

"Uncover the evidence-based science to slowing the effects of aging, from the New York Times bestselling author of the How Not to Die series When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don't need Big Pharma to keep us feeling young-we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life. Physicians have long treated aging as a malady, but getting older does not have to mean getting sicker. There are eleven pathways for aging in our bodies' cells and we can disrupt each of them. Processes like autophagy, the upcycling of unusable junk, can be boosted with spermidine, a compound found in tempeh, mushrooms, and wheat germ. Senescent "zombie" cells that spew inflammation and are linked to many age-related diseases may be cleared in part with quercetin-rich foods like onions, apples, and kale. And we can combat effects of aging without breaking the bank. Why spend a small fortune on vitamin C and nicotinamide facial serums when you can make your own for up to 2,000 times cheaper? Inspired by the dietary and lifestyle patterns of centenarians and residents of "blue zone" regions where people live the longest, Dr. Greger presents simple, accessible, and evidence-based methods to preserve the body functions that keep you feeling youthful, both physically and mentally. Brimming with expertise and actionable takeaways, How Not to Age lays out practical strategies for achieving ultimate longevity"--

James Fadiman, an early psychedelic researcher, and co-author Jordan Gruber’s MICRODOSING FOR HEALTH, HEALING AND ENHANCED PERFORMANCE is the first comprehensive book on microdosing, using new research and extensive reports from individuals to describe the possibilities of the practice. Microdosing is proving to be a safe and powerful approach to a wide range of health conditions and enhanced performance. Partly responsible for modern microdosing’s development and current popularity, the authors answer hundreds of questions, blending extensive research with detailed personal accounts from contributors worldwide. The book also contains wide-ranging microdosing history, research, and science. People have microdosed successfully: · to alleviate symptoms of depression, ADHD, chronic pain, and long COVID · for enhanced focus, mental acuity, and physical abilities (including sports) · to help taper off pharmaceuticals, especially antidepressants and stimulants · to improve food habits, sleep, and relationships · to become more aware of personal habit patterns, others’ feelings, and natural surroundings · to reduce stress and anxiety · to help over 30 specific health concerns This book does not provide medical or legal advice. Readers should speak to their doctor before engaging in any course of microdosing.

*A New York Times Editors' Choice Pick* An "ambitious work" ( Washington Post ) tracing the links between autism and ingenuity Is the ability to invent things unique to humans? In The Pattern Seekers , Cambridge University psychologist Simon Baron-Cohen argues that it is, and proposes that autistic people have played a key role in human progress for seventy to one hundred thousand years, from the first complex tools like the bow and arrow and the first musical instrument to the digital revolution. He presents the science that the same genes that contribute to autism enable a special kind of pattern seeking that is essential to our species' inventiveness. However, these abilities come at a cost for autistic people, including social and neurological challenges. Baron-Cohen calls on us to support and celebrate autistic people in both their disabilities and their talents. Ultimately, The Pattern Seekers isn't just a new theory of human evolution, but a call to reconsider how society treats those who think differently.

With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments, "Molecular Cell Biology" has justly earned an impeccable reputation as an authoritative and exciting text. The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors.

The New York Times bestselling book of simple rules everyone should follow in order to live a long, healthy life, featuring illustrations throughout, from the author of The End of Illness . In his international bestseller, The End of Illness , Dr. David B. Agus shared what he has learned from his work as a pioneering cancer doctor, revealing the innovative steps he takes to prolong the lives of not only cancer patients, but those who want to enjoy a vigorous, lengthy life. Now Dr. Agus has turned his research into a practical and concise illustrated handbook for everyday living. He believes optimal health begins with our daily routines. A Short Guide to a Long Life is divided into three sections (What to Do, What to Avoid, and Doctor’s Orders) that provide the definitive answers to many common and not-so-common questions: Who should take a baby aspirin daily? Are flu shots safe? What constitutes “healthy” foods? Why is it important to protect your senses? Are airport scanners hazardous? Dr. Agus will help you develop new patterns of personal health care, using inexpensive and widely available tools that are based on the latest and most reliable science. An accessible and essential handbook for preparing for visits to the doctor and maintaining control of your future , “ A Short Guide to a Long Life explores the simple idea that a healthy tomorrow starts with good habits today” ( Fortune ).

Joining the ranks of modern myth busters, Dr. Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria. So why does disease exist? Moalem proposes that most common ailments--diabetes, hemochromatosis, cystic fibrosis, sickle cell anemia--came into existence for very good reasons. At some point they helped our ancestors survive some grand challenge to their existence. Examining the evolution of man, Moalem reveals the role genetic and cultural differences have played in the health and well-being of various races, including their susceptibility to disease. With mesmerizing insight, Moalem offers groundbreaking insight into: - How diabetes may be a biproduct of a mechanism that helped humans survive the Ice Age - Why African Americans living in the north might suffer from vitamin D deficiencies, - Why Asians can't drink as much alcohol as Europeans Revelatory, utterly engaging, and timely--Moalem ponders strongN1, the emerging Avian Flu virus--Why Redheads Feel More Pain and Asians Can't Drink will irrevocably change the way we think about our bodies and ourselves.

The untold story of how poison rocked Jazz Age New York City. A pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Chief medical examiner Charles Norris and toxicologist Alexander Gettler investigate a family mysteriously stricken bald, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler create revolutionary experiments to tease out even the wiliest compounds from human tissue. From the vantage of their laboratory it also becomes clear that murderers aren't the only toxic threat--modern life has created a kind of poison playground, and danger lurks around every corner.

The ability to manipulate information has become the single most important element of success. High intelligence is an increasingly precious raw material. But despite decades of fashionable denial, the overriding and insistent truth about intellectual ability is that it is endowed unequally.In this audio presentation of The Bell Curve , author Charles Murray explores the ways that low intelligence, independent of social, economic, or ethnic background, lies at the root of many of our social problems. He also discusses another taboo that intelligence levels differ among ethnic groups.According to the authors, only by facing up to these differences can we accurately assess the nation's problems and make realistic plans to address them. However, if we accept that there are intelligence differences among groups, we must learn to avoid prejudicial assumptions about any individual of a given group whose intelligence level may be anywhere under the bell curve.

NEW YORK TIMES BESTSELLER • From the acclaimed author of Signal Fires and host of the hit podcast Family Secrets : a memoir about the staggering family secret uncovered by a genealogy test, an exploration of the urgent ethical questions surrounding fertility treatments and DNA testing, and a profound inquiry of paternity, identity, and love. “Memoir gold: a profound and exquisitely rendered exploration of identity and the true meaning of family.” — People In the spring of 2016, through a genealogy website to which she had casually submitted her DNA for analysis, Dani Shapiro received the stunning news that her beloved deceased father was not her biological father. Over the course of a single day, her entire history—the life she had lived—crumbled beneath her. Inheritance is a book about secrets. It is the story of a woman's urgent quest to unlock the story of her own identity, a story that had been scrupulously hidden from her for more than fifty years. It is a book about the extraordinary moment we live in, a moment in which science and technology have outpaced not only medical ethics but also the capacities of the human heart to contend with the consequences of what we discover. Dani Shapiro’s memoir unfolds at a breakneck pace—part mystery, part real-time investigation, part rumination on the ineffable combination of memory, history, biology, and experience that makes us who we are. Inheritance is a devastating and haunting interrogation of the meaning of kinship and identity, written with stunning intensity and precision.

"For as long as he has served at the highest levels of business and government, Vice President Dick Cheney has also been one of the world's most prominent heart patients. Now, for the first time ever, Cheney, together with his longtime cardiologist Jonathan Reiner, MD, shares the very personal story of his courageous thirty-five-year battle with heart disease, from his first heart attack in 1978 to the heart transplant he received in 2012. In 1978, when Cheney suffered his first heart attack, he received essentially the same treatment as President Eisenhower had in 1955. Since then, cardiac medicine has evolved in extraordinary ways, and Cheney has benefited from nearly every medical and technological breakthrough along the way. At each juncture, when Cheney faced a new health challenge, the technology was one step ahead of his disease. In many ways, Cheney's story is the story of the evolution of modern cardiac care. Heart is the riveting, singular memoir of both doctor and patient, tracking their relationship as it unfolds over many years and crises. Like no US politician has before him, Cheney opens up about his health struggles, sharing harrowing, never-before-told stories about the challenges he faced during a perilous time in our nation's history. Dr. Reiner provides his perspective on Cheney's case and also gives readers a fascinating glimpse into his own education as a doctor. He masterfully chronicles the important discoveries, radical innovations, and cutting-edge science that have changed the face of medicine and saved countless lives. Powerfully braiding science with story and the personal with the political, Heart is a sweeping, inspiring, and ultimately optimistic book that will give hope to the millions of Americans affected by heart disease"--

"What happens when a society elevates victimhood to a virtue and decides that punishment is cruel? You get the disease Dr. Gad Saad calls suicidal empathy. And the West may be terminally infected" --

''Mind blowingly brilliant'' PHILIPPA PERRY''Few other writers have such passion for granular detail, intellectual heft and boundless curiosity'' THE TIMES''As suspenseful and pacy as an episode of peak-era ER'' GUARDIANA near-fatal health emergency leads to this powerful reflection on death―and what might follow―by the bestselling author of Tribe and The Perfect Storm.For years as an award-winning war reporter, Sebastian Junger travelled to many front lines and frequently put his life at risk. And yet the closest he ever came to death was the summer of 2020 while spending a quiet afternoon at the New England home he shared with his wife and two young children. Crippled by abdominal pain, Junger was rushed to the hospital by ambulance. Once there, he began slipping away. As blackness encroached, he was visited by his dead father, inviting Junger to join him. “It’s okay,” his father said. “There’s nothing to be scared of. I’ll take care of you.” That was the last thing Junger remembered until he came to the next day when he was told he had suffered a ruptured aneurysm that he should not have survived.This experience spurred Junger―a confirmed atheist raised by his physicist father to respect the empirical―to undertake a scientific, philosophical, and deeply personal examination of mortality and what happens after we die. How do we begin to process the brutal fact that any of us might perish unexpectedly on what begins as an ordinary day? How do we grapple with phenomena that science may be unable to explain? And what happens to a person, emotionally and spiritually, when we are forced to reckon with such existential questions?In My Time of Dying is part medical drama, part searing autobiography, and part rational inquiry into the ultimate unknowable mystery.''Moving, compact, philosophically ambitious … A humbling volume'' OBSERVER‘Stunning … A powerful book that comes as close as anything I’ve read in explaining what it means to be human’ JAMES PATTERSON''An instant classic that filled me with wonder, gratitude and awe'' WILL SCHWALBE''A stunning account I didn’t so much read as inhale, awed and riveted and forever changed'' MICHAEL FINKEL

An eye-opening investigation into the history of diabetes research and treatment by the award-winning journalist and best-selling author of Why We Get Fat • "[Gary] Taubes’s meticulous, science-based work makes him the Bryan Stevenson of nutrition, an early voice in the wilderness for an unorthodox view that is increasingly becoming accepted."—Niel Barsky , The Guardian Before the discovery of insulin, diabetes was treated almost exclusively through diet, from subsistence on meat, to reliance on fats, to repeated fasting and near-starvation regimens. After two centuries of conflicting medical advice, most authorities today believe that those with diabetes can have the same dietary freedom enjoyed by the rest of us, leaving the job of controlling their disease to insulin therapy and other blood-sugar-lowering medications. Rather than embark on “futile” efforts to restrict sugar or carbohydrate intake, people with diabetes can lead a normal life, complete with the occasional ice-cream cake, side of fries, or soda. These guiding principles, however, have been accompanied by an explosive rise in diabetes over the last fifty years, particularly among underserved populations. And the health of those with diabetes is expected to continue to deteriorate inexorably over time, with ever-increasing financial, physical, and psychological burdens. In Rethinking Diabetes, Gary Taubes explores the history underpinning the treatment of diabetes, types 1 and 2, elucidating how decades-old research that is rife with misconceptions has continued to influence the guidance physicians offer—at the expense of their patients’ long-term well-being. The result of Taubes’s work is a reimagining of diabetes care that argues for a recentering of diet—particularly, fewer carbohydrates and more fat—over a reliance on insulin. Taubes argues critically and passionately that doctors and medical researchers should question the established wisdom that may have enabled the current epidemic of diabetes and obesity, and renew their focus on clinical trials to resolve controversies that are now a century in the making.

Here are some facts: Women live longer than men. They have stronger immune systems. They're better at fighting cancer and surviving famine, and even see the world in a wider variety of colours. They are simply stronger than men at every stage of life. Why is this? And why are we taught the opposite? To find out, Dr. Sharon Moalem drew on his own medical experiences - treating premature babies in the neonatal intensive care unit; recruiting the elderly for neurogenetic studies; tending to HIV-positive orphans in Thailand - and tried to understand why in every instance men were consistently less likely to thrive. The answer, he discovered, lies in our genetics: two X chromosomes offer a powerful survival advantage. With clear, captivating prose that weaves together eye-opening research, case studies, diverse examples ranging from the behaviour of honeybees to American pioneers, as well as experiences from his personal life and his own patients, Moalem explains why genetic females triumph over males when it comes to resiliency, intellect, stamina, immunity and much more. He also calls for a reconsideration of our male-centric, one-size-fits-all view of medical studies and even how we prescribe medications - a view that still sees women through the lens of men. Revolutionary and yet utterly convincing, The Better Half will make you see humanity and the survival of our species anew.[Bokinfo]