This tale of two families is set on a grand scale, as James Thomas Flexner brings his talents to bear on his own noteworthy heritage. An American Saga is an historical narrative, grounded on documentary sources, which ends with the marriage of Helen Thomas and Simon Flexner. The account deals equally with the lives and the backgrounds of husband and wife, the author's parents. Simon Flexner was the famous medical investigator, discoverer of the "Flexner vacillus" and the "Flexner serum," who became the creating director of the Rockefeller Institute for Medical Research (now Rockefeller University) and eventually acknowledged leader of American medical science. The Kentucky-born son of impoverished German Jewish immigrants, he grew up in penury. As he never completed the eighth grade, he was almost completely self-educated when he appeared at the Johns Hopkins University before its celebrated medical school had been founded. Almost instantly he began making the discoveries that soon made him the leading younger medical scientist in the United States.

Spaceflight historian Amy Shira Teitel tells the riveting story of the female pilots who each dreamed of being the first American woman in space. When the space age dawned in the late 1950s, Jackie Cochran held more propeller and jet flying records than any pilot of the twentieth century-man or woman. She had led the Women's Auxiliary Service Pilots during the Second World War, was the first woman to break the sound barrier, ran her own luxury cosmetics company, and counted multiple presidents among her personal friends. She was more qualified than any woman in the world to make the leap from atmosphere to orbit. Yet it was Jerrie Cobb, twenty-five years Jackie's junior and a record-holding pilot in her own right, who finagled her way into taking the same medical tests as the Mercury astronauts. The prospect of flying in space quickly became her obsession. While the American and international media spun the shocking story of a "woman astronaut" program, Jackie and Jerrie struggled to gain control of the narrative, each hoping to turn the rumored program into their own ideal reality-an issue that ultimately went all the way to Congress. This dual biography of audacious trailblazers Jackie Cochran and Jerrie Cobb presents these fascinating and fearless women in all their glory and grit, using their stories as guides through the shifting social, political, and technical landscape of the time.