You will automatically receive a 3 month FREE subscription to Harrison's Online 2.0 with your purchase of the HARRISON textbook. Eminently readable, completely current, and dramatically revised, the new fifteenth edition of Harrison's PRINCIPLES OF INTERNAL MEDICINE raises the bar for internal medicine references. Featuring over 90 completely new chapters, HARRISON'S continues to provide the most authoritative record of internal medicine as practiced by the leading experts in the field. And it gives you the one comprehensive database that covers the full spectrum of issues you need to know NOW - basic science, pathophysiology, presenting clinical signs, diagnosis, and the latest treatment guidelines. * Expanded treatment with more algorithms and diagnostic decision trees * A new feature, Genetic Considerations, describes how new advances affect patient care * Clinical Guidelines now added throughout, provide evidence-based treatment strategies * Alternative Medicine...a detailed chapter covers this emerging field * New Chapter on Late Problems in Patients with Cancer * New guidelines on Adolescent Health Care * The latest in Gene Therapy with a new chapter on Screening, Prevention, and Counseling for Genetic Disorders * New chapter on Infertility and Fertility Control * Neurobiology of Disease highlights numerous advances made during "The disease of the Brain" * Late-breaking treatment information on multiple sclerosis, Parkinson's disease, Alzheimer's and more * A new color atlas of malaria-infected red blood cells

*A New York Times Editors' Choice Pick* An "ambitious work" ( Washington Post ) tracing the links between autism and ingenuity Is the ability to invent things unique to humans? In The Pattern Seekers , Cambridge University psychologist Simon Baron-Cohen argues that it is, and proposes that autistic people have played a key role in human progress for seventy to one hundred thousand years, from the first complex tools like the bow and arrow and the first musical instrument to the digital revolution. He presents the science that the same genes that contribute to autism enable a special kind of pattern seeking that is essential to our species' inventiveness. However, these abilities come at a cost for autistic people, including social and neurological challenges. Baron-Cohen calls on us to support and celebrate autistic people in both their disabilities and their talents. Ultimately, The Pattern Seekers isn't just a new theory of human evolution, but a call to reconsider how society treats those who think differently.

Margaret S. Mahler and her collaborators break new ground in developmental psychology and present the first complete theoretical statement of Dr. Mahler's observations on the normal separation-individuation process.Separation and individuation are presented in this major work as two complementary developments. Separation is described as the child's emergence from a symbiotic fusion with the mother, while individuation consists of those achievements marking the child's assumption of his own individual characteristics. Each of the subphases of separation-individuation is described in detail, supported by a wealth of clinical observations which trace the tasks confronting the infant and his mother as he progresses toward achieving his own individuality.A number of chapters are devoted to following five children epigenetically through their subphase development. A separate section describes the authors' methodology, the importance of the research setting, and the effects of changes in the setting. The extensive appendices by Fred Pine discuss the uniqueness of the data-gathering techniques used by the authors. In addition, a useful glossary of concepts defines the new terms that Dr. Mahler has introduced.This book represents an important breakthrough in understanding the human infant and makes a unique contribution to the science of human behavior.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.

Can we download our consciousness, and if so where should the backup be stored? Why is it that we can drive tired, but not drunk (when sleepiness has caused many more accidents)? What senses would we want to add if we could expand our perception? What types of crimes might we face in an era of neural implants? What would learning look like if humans could transmit thoughts across brains? How can we improve (/ruin) relationships, sex, and intimacy using cross-brain communication? And what can the business world do as it prepares for a world of mind reading? Those and other issues that are at the forefront of current neuroscience research are addressed in a sequence of comical and thought-provoking illustrations by Moran Cerf, professor of neuroscience and business. This graphical visualization of our future makes readers of all ages - kids and adults alike - laugh, and then think.

In this ground breaking work, Langs turns to evolutionary biology, the fundamental theory of biological sciences, to derive a set of principles that deeply reform psychoanalytic theory and practice. In doing so he makes a profound announcement of the new field of Evolutionary Psychoanalysis and continues his long-standing project of expanding classical psychoanalysis by forging connections with other biological sciences.

Focus in the media on the risks posed to ordinary people has become increasingly strong in recent years - particularly on those risks popularly perceived to be posed by the mentally ill. But how justified is this concern? How do we best manage so-called dangerous people? In Will They Do It Again? Herschel Prins considers the issue of public protection within a broad context of risk in society generally, examining the concerns arising in contemporary society from dealing with uncertainty. It is argued that public fear over the danger posed by the mentally ill is at odds with the evidence, and that much of the concern is focused on a small number of high-profile cases. Prins goes on to examine such cases where management of the mentally ill has failed and sets out suggestions for improvements in practice. Will They Do It Again? cuts through popular misunderstanding and media hype over risk to give a clear, unbiased picture of the real risks to society from the mentally ill and how best they can be contained and managed, and will prove invaluable to a range of practitioners involved in the fields of criminal justice and psychiatry.

In this remarkable book by one of the great psychologists and neurologists of the early twentieth century, Kurt Goldstein presents a summation of his “holistic” theory of the human organism. In the course of his studies on brain-damaged soldiers during the First World War, Goldstein became aware of the failure of contemporary biology and medicine to genuinely understand both the impact of such injuries and the astonishing adjustments that patients made to them. He challenged reductivist approaches that dealt with “localized” symptoms, insisting instead that an organism be analyzed in terms of the totality of its behavior and interaction with its surrounding milieu. He was especially concerned with the breakdown of organization and the failure of central cerebral controls that take place in catastrophic responses to situations such as physical or mental illness. But Goldstein was equally attuned to the amazing powers of the organism to readjust to such devastating losses, if only by withdrawal to a more limited range of activity that it could manage by a redistribution of its reduced energies, thus reclaiming as much wholeness as new circumstances allowed. Goldstein’s concepts in The Organism have had a major impact on philosophical and psychological thought throughout this century, as can be seen in the work of Maurice Merleau-Ponty, Georges Canguilhem, Ernst Cassirer, Ludwig Binswanger, and Roman Jakobson, not to mention the wide-ranging field of Gestalt psychology.

Partial table of contents: NEUROPEPTIDES AND THE STRESS RESPONSE. Brain Corticotropin Releasing Factor and Development (T. Insel, et al.). Opioids, Stress, and the Developing Brain (I. Zagon & P. McLaughlin). THE ADRENAL MEDULLA AND STRESS. Catecholamines and Stress in the Newborn (T. Slotkin & F. Seidler). Endogeneous Neuropeptides Maintain Adrenal Catecholamine Output during Stress (B. Livett, et al.). IMMUNOBIOLOGY OF STRESS. Shock Induced Immunosuppression: Naltrexone Sensitive and Insensitive Parameters (J. Cunnick, et al.). Regulation of Interleukin-2 Expression by Dexamethasone in a Mouse T Cell Line (B. Sorg, et al.). PHYSICAL CONSEQUENCES OF STRESS. Enzymatic and Morphological Adaptation to Physical Exercise in Young Middle Aged, and Old Mice: A Model for Physical Stress (A. Reznick, et al.). Gastric Erosion Formation by Stress: Brain Stem Mechanisms (H. Weiner, et al.). STRESS AND BEHAVIOR. Information-Induced Stress in Humans (S. Breznitz). Affect Specific Retrieval from Archival Memory (H. Weingartner, et al.). Index.

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Mental Chronometry (MC) comprises a variety of techniques for measuring the speed with which the brain processes information. First developed in mid-1800, MC was subsequently eclipsed by more complex and practically useful types of psychometric tests stemming from Alfred Binet. This class of mental tests, however, has no true metric relating the test scores to any specific properties of the brain per se. The scores merely represent an ordinal scale, only ranking individuals according to their overall performance on a variety of complex mental tasks. The resulting scores represent no more than ranks rather than being a true metrical scale of any specific dimension of brain function. Such an ordinal scale, which merely ranks individuals in some defined population, possesses no true scale properties, possessing neither a true zero or equal intervals throughout the scale. This deficiency obstructs the development of a true natural science of mental ability. The present burgeoning interest in understanding individual differences in mental abilities in terms of the natural sciences, biology and the brain sciences in particular, demands direct measures that functionally link brain and behavior. One such natural ratio scale is time itself - the time it takes the brain to perform some elementary cognitive task, measured in milliseconds. After more than 25 years researching MC, Jensen here presents results on an absolute scale showing times for intake of visual and auditory information, for accessing short-term and long-term memory, and other cognitive skills, as a function of age, at yearly intervals from 3 to 80 years. The possible uses of MC in neurological diagnosis and the monitoring of drug effects on cognition, the chronometric study of special time-sensitive talents such as musical performance, and presents a theory of general intelligence, or g, as a function of the rate of oscillation of neural action potentials as

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