*A New York Times Editors' Choice Pick* An "ambitious work" ( Washington Post ) tracing the links between autism and ingenuity Is the ability to invent things unique to humans? In The Pattern Seekers , Cambridge University psychologist Simon Baron-Cohen argues that it is, and proposes that autistic people have played a key role in human progress for seventy to one hundred thousand years, from the first complex tools like the bow and arrow and the first musical instrument to the digital revolution. He presents the science that the same genes that contribute to autism enable a special kind of pattern seeking that is essential to our species' inventiveness. However, these abilities come at a cost for autistic people, including social and neurological challenges. Baron-Cohen calls on us to support and celebrate autistic people in both their disabilities and their talents. Ultimately, The Pattern Seekers isn't just a new theory of human evolution, but a call to reconsider how society treats those who think differently.

With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments, "Molecular Cell Biology" has justly earned an impeccable reputation as an authoritative and exciting text. The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors.

Joining the ranks of modern myth busters, Dr. Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria. So why does disease exist? Moalem proposes that most common ailments--diabetes, hemochromatosis, cystic fibrosis, sickle cell anemia--came into existence for very good reasons. At some point they helped our ancestors survive some grand challenge to their existence. Examining the evolution of man, Moalem reveals the role genetic and cultural differences have played in the health and well-being of various races, including their susceptibility to disease. With mesmerizing insight, Moalem offers groundbreaking insight into: - How diabetes may be a biproduct of a mechanism that helped humans survive the Ice Age - Why African Americans living in the north might suffer from vitamin D deficiencies, - Why Asians can't drink as much alcohol as Europeans Revelatory, utterly engaging, and timely--Moalem ponders strongN1, the emerging Avian Flu virus--Why Redheads Feel More Pain and Asians Can't Drink will irrevocably change the way we think about our bodies and ourselves.

An eye-opening investigation into the history of diabetes research and treatment by the award-winning journalist and best-selling author of Why We Get Fat • "[Gary] Taubes’s meticulous, science-based work makes him the Bryan Stevenson of nutrition, an early voice in the wilderness for an unorthodox view that is increasingly becoming accepted."—Niel Barsky , The Guardian Before the discovery of insulin, diabetes was treated almost exclusively through diet, from subsistence on meat, to reliance on fats, to repeated fasting and near-starvation regimens. After two centuries of conflicting medical advice, most authorities today believe that those with diabetes can have the same dietary freedom enjoyed by the rest of us, leaving the job of controlling their disease to insulin therapy and other blood-sugar-lowering medications. Rather than embark on “futile” efforts to restrict sugar or carbohydrate intake, people with diabetes can lead a normal life, complete with the occasional ice-cream cake, side of fries, or soda. These guiding principles, however, have been accompanied by an explosive rise in diabetes over the last fifty years, particularly among underserved populations. And the health of those with diabetes is expected to continue to deteriorate inexorably over time, with ever-increasing financial, physical, and psychological burdens. In Rethinking Diabetes, Gary Taubes explores the history underpinning the treatment of diabetes, types 1 and 2, elucidating how decades-old research that is rife with misconceptions has continued to influence the guidance physicians offer—at the expense of their patients’ long-term well-being. The result of Taubes’s work is a reimagining of diabetes care that argues for a recentering of diet—particularly, fewer carbohydrates and more fat—over a reliance on insulin. Taubes argues critically and passionately that doctors and medical researchers should question the established wisdom that may have enabled the current epidemic of diabetes and obesity, and renew their focus on clinical trials to resolve controversies that are now a century in the making.

Here are some facts: Women live longer than men. They have stronger immune systems. They're better at fighting cancer and surviving famine, and even see the world in a wider variety of colours. They are simply stronger than men at every stage of life. Why is this? And why are we taught the opposite? To find out, Dr. Sharon Moalem drew on his own medical experiences - treating premature babies in the neonatal intensive care unit; recruiting the elderly for neurogenetic studies; tending to HIV-positive orphans in Thailand - and tried to understand why in every instance men were consistently less likely to thrive. The answer, he discovered, lies in our genetics: two X chromosomes offer a powerful survival advantage. With clear, captivating prose that weaves together eye-opening research, case studies, diverse examples ranging from the behaviour of honeybees to American pioneers, as well as experiences from his personal life and his own patients, Moalem explains why genetic females triumph over males when it comes to resiliency, intellect, stamina, immunity and much more. He also calls for a reconsideration of our male-centric, one-size-fits-all view of medical studies and even how we prescribe medications - a view that still sees women through the lens of men. Revolutionary and yet utterly convincing, The Better Half will make you see humanity and the survival of our species anew.[Bokinfo]

"Titillating and provocative essays from one of the freshest voices in science today -- Why do testicles hang the way they do? Is there an adaptive function to the female orgasm? What does it feel like to want to kill yourself? Does "free will" really exist? And why is the penis shaped like that anyway? In Why Is the Penis Shaped Like That?, the research psychologist and award-winning columnist Jesse Bering features more than thirty of his most popular essays from Scientific American and Slate, as well as two new pieces, that take readers on a bold and captivating journey through some of the most taboo issues related to evolution and human behavior. Exploring the history of cannibalism, the neurology of people who are sexually attracted to animals, the evolution of human body fluids, the science of homosexuality, and serious questions about life and death, Bering astutely covers a generous expanse of our kaleidoscope of quirks and origins. With his characteristic irreverence and trademark cheekiness, Bering leaves no topic unturned or curiosity unexamined, and he does it all with an audaciously original voice. Whether you are interested in the psychological history behind the many facets of sexual desire or the evolutionary patterns that have dictated our current mystique and phallic physique, Why Is the Penis Shaped Like That? is bound to create lively discussion and debate for years to come"--

The exclusive, first-hand, behind-the-scenes story of how Pfizer raced to create the first Covid-19 vaccine, told by Pfizer's CEO Dr. Albert Bourla A riveting, fast-paced, inside look at one of the most incredible private sector achievements in history, Moonshot recounts the intensive nine months in 2020 when the scientists at Pfizer, under the visionary leadership of Dr. Albert Bourla, made "the impossible possible"--creating, testing, and manufacturing a safe and effective Covid-19 vaccine that previously would have taken years to develop. Dr. Bourla chronicles how the brilliant, dedicated minds at Pfizer, under the enormous strains of the global pandemic, overcame a series of crises that were compounded by social and political unrest, and reveals the doubts, decisions, obstacles, and failures they encountered. As Dr. Bourla makes clear, Pfizer's success wasn't due to luck; it was because of preparation driven by four simple values--Courage, Excellence, Equity, and Joy. Moonshot is a story of leadership under the most unprecedented circumstances--how Dr. Bourla, a Greek immigrant, a child of Holocaust survivors, and a veterinarian, became the head of one of the world's largest corporations and initiated a dramatic transformation of the organization just before a global health crisis would serve to test the organization, its scientists and its leader, like never before. Moonshot describes best practices that can be used to address the multiple, unprecedented challenges our world faces, reveals Pfizer's implementation of scientific breakthroughs at a record-breaking pace, and offers leadership lessons that can help anyone successfully manage their own seemingly unsolvable problems. As Dr. Bourla explains, "I am sharing the story of our moonshot--the challenges we faced, the lessons we learned, and the core values that allowed us to make it happen--in hopes that it might inspire and inform your own moonshot, whatever that may be."

Soul Made Flesh is the remarkable untold story of a dramatic turning point in history, the exciting discovery of how the human brain works. In an unprecedented examination of how the secrets of the brain were revealed in seventeenth-century England, award-winning author Carl Zimmer tells an extraordinary tale that unfurls against a deadly backdrop of civil war, plague, and the Great Fire of London. At the beginning of that turbulent century, no one knew how the brain worked or even what it looked like intact. By the century's close, the science of the brain had taken root, helping to overturn many of the most common misconceptions and dominant philosophies about man, God, and the universe. Presiding over the rise of this new scientific paradigm was the founder of modern neurology, Thomas Willis, a fascinating, sympathetic, even heroic figure who stands at the center of an extraordinary group of scientists and philosophers known as the Oxford circle. Chronicled here in vivid detail are their groundbreaking revelations and often gory experiments that first enshrined the brain as the chemical engine of reason, emotion, and madness, indeed as the very seat of the human soul. Called 'as fine a science essayist as we have' by The New York Times, Zimmer tells the story of this scientific revolution through the lives of a colorful array of alchemists, mystics, utopians, spies, revolutionaries, and kings. He recreates the religious, ethical, and scientific struggles involved in the pioneering autopsies of the brain carried out by Thomas Willis; the discovery of the circulation of blood by William Harvey and his flight from London with his besieged king, Charles I; René Descartes's persecution by Catholics and Protestants alike for his views of the brain and soul; and the experiments and personal dramas of gifted men who forever changed the way science is practiced as they simultaneously upended our view of our human selves and our place in the world. In this distant mirror to our own time of continuing scientific revolution and worldwide social upheaval, Zimmer brings to life the painstaking, innovative discoveries of Willis and his contemporaries, the taproots of the amazing work of today's neuroscientists, who continue to explore the brain, revealing the hidden workings of emotions, memories, and consciousness. Graced with beautiful illustrations by Christopher Wren, Soul Made Flesh conveys a contagious appreciation for the wonder of the brain, its structure, its many marvelous functions, and the implications for human identity, mind, and morality. It is the definitive history of the dawn of a world-changing science and attitude, the age of the brain and modern consciousness.

"Totem and Taboo" is a collection of four essays by Sigmund Freud that were published together in German in 1913. Freud sought to apply his theories of psychoanalysis to the study of anthropology and early human history. The four essays cover a wide range of topics. In "The Horror of Incest", Freud examines the varied and common rules in primitive cultures that limit contact between members of the same family. In "Taboo and Emotional Ambivalence," Freud posits that primitive cultures and their attitudes about magical objects are similar to the behavior of people with neurotic psychological conditions in the modern world. In "Animism, Magic and the Omnipotence of Thought," Freud draws comparisons between the primitive belief in magic and magical animals to obsessive and compulsive disorders. Finally, in "The Return of Totemism in Childhood," Freud, influenced by one of Charles Darwin's theories about the male-dominated arrangement of early human societies, looks for parallels with his own Oedipus complex theory in the structure of primitive cultures. A classic and influential work of early psychoanalysis, "Totem and Taboo" is an important read for students of both psychology and social anthropology.

hardcover medical research book

A vibrant cultural history investigating pandemics and vaccines, by bestselling author and historian Simon Schama Cities and countries engulfed by panic and death, desperate for vaccines but fearful of what inoculation may bring. This is what the world has just gone through with Covid-19. But as Simon Schama shows in his epic history of vulnerable humanity caught between the terror of contagion and the ingenuity of science, it has happened before. Characteristically, Schama's message is delivered through gripping, page-turning stories set in the eighteenth and nineteenth centuries: smallpox strikes London; cholera hits Paris; plague comes to India. Threading through the scenes of terror, suffering and hope - in hospitals and prisons, palaces, and slums - are an unforgettable cast of characters: a philosopher-playwright burning up with smallpox in a country chateau; a vaccinating doctor paying house calls in Halifax; a woman doctor in south India driving her inoculator-carriage through the stricken streets as dead monkeys drop from the trees. But we are also in the labs when great, life-saving breakthroughs happen, in Paris, Hong Kong, and Mumbai. At the heart of it all is an unsung hero: Waldemar Haffkine, a gun-toting Jewish student in Odesa turned microbiologist at the Pasteur Institute, hailed in England as "the saviour of mankind" for vaccinating millions against cholera and bubonic plague in British India while being cold-shouldered by the medical establishment of the Raj. Creator of the world's first mass production line of vaccines in Mumbai, he is tragically brought down in an act of shocking injustice. Foreign Bodies crosses borders between east and west, Asia and Europe, the worlds of rich and poor, politics and science. Its thrilling story carries with it the credo of its author on the interconnectedness of humanity and nature; of the powerful and the people. Ultimately, Schama says, as we face the challenges of our times together, "there are no foreigners, only familiars."

From the author of the #1 national bestselling Musicophilia comes a truly visionary book: an exploration of the remarkable, unpredictable ways that our brains cope with the loss of sight by finding new forms of perception to create worlds as complete and rich as the no-longer-visible world. Following the phenomenal success of his international bestseller Musicophilia , the inimitable Oliver Sacks returns with another book on the extraordinary interaction between our brain and our senses -- in this case, vision. In The Mind's Eye , Sacks examines questions ranging from the primary experiences of how we perceive depth or color or motion to the complex matter of how different individuals have varied ways of thinking and experiencing or recreating the visual world. Like The Man Who Mistook His Wife for a Hat and An Anthropologist on Mars , Sacks's new book is based primarily on individual stories -- including Sacks's own experience of an ocular tumor that left him unable to perceive depth. As always, he embeds these case histories in a rich historical and scientific context. Sacks goes beyond basic vision to explore perception, hallucination and the power of visualization, as well as the ocular effects of migraine, epilepsy and other conditions. Oliver Sacks is our perfect guide to the visual world, a realm that, it turns out, is much, much more complicated than we could have imagined.

A New York Times Book Review Editors’ Choice Named a Best Book of the Year by Bloomberg (Chosen by Philip Tetlock), Booklist ’s Top 10 Science Books of the Year, and Shortlisted for Physics World ’s Book of the Year A Major Biography of the Nobel Prize–Winning Physicist, Enrico Fermi, a Leading Architect of the Atomic Age Enrico Fermi is unquestionably among the greats of the world’s physicists, the most famous Italian scientist since Galileo. Called “the Pope” by his peers, he was regarded as infallible in his instincts and research. His discoveries changed our world; they led to weapons of mass destruction and conversely to life-saving medical interventions. This unassuming man struggled with issues relevant today, such as the threat of nuclear annihilation and the relationship of science to politics. Fleeing Fascism and anti-Semitism, Fermi became a leading figure in America’s most secret project: building the atomic bomb. An examination of the human dramas that touched Fermi’s life as well as a thrilling history of scientific innovation in the twentieth century, this is the comprehensive biography that Fermi deserves.

A Nobel Prize–winning cancer biologist, leader of major scientific institutions, and scientific adviser to President Obama reflects on his remarkable career. A PhD candidate in English literature at Harvard University, Harold Varmus discovered he was drawn instead to medicine and eventually found himself at the forefront of cancer research at the University of California, San Francisco. In this “timely memoir of a remarkable career” ( American Scientist ), Varmus considers a life’s work that thus far includes not only the groundbreaking research that won him a Nobel Prize but also six years as the director of the National Institutes of Health; his current position as the president of the Memorial Sloan-Kettering Cancer Center; and his important, continuing work as scientific adviser to President Obama. From this truly unique perspective, Varmus shares his experiences from the trenches of politicized battlegrounds ranging from budget fights to stem cell research, global health to science publishing.

"A collection of diverse viewpoints from over 45 thought leaders in the biotechnology industry and their efforts going forward during the COVID-19 pandemic. Biotechnology in the Time of COVID-19 is the opening chapter of a story of how the biotechnology industry rose to battle the COVID-19 virus-told by the leaders of that industry in their own words. The industry has built over more than forty years, an ecosystem of scientists, entrepreneurs, doctors, investors, venture capitalists, analysts, media, and bankers, all committed to advancing global health. In two months, leaders and companies from this ecosystem pivoted from the work they were carrying on pre-COVID-19 to face the virus. Forty-six seven contributors offer historical, personal, and investor perspectives, views from inside the biotech companies, broad lessons, leadership, and a look to the future. COVID-19 was a crisis anticipated by many, but one for which we were inadequately prepared. That has led to an unnecessary catastrophe. Now is the time to shine a light on those who bring hope that we will push back the virus with science and medicine. This book is a collection of the voices from the front of that fight. All share the commitment to fight and the conviction that science and medicine will prevail. The editor royalties and a portion of publisher revenues will be donated to two nonprofits focused on rare disease research: Global Genes (globalgenes.org) and The Institute for Life Changing Medicines (lifechangingmedicines.org)"--

From Pulitzer Prize-winning Washington Post reporter Eli Saslow, a powerful portrait of a country grappling with the pandemic, told through voices of people from all across America The Covid-19 pandemic was a world-shattering event, affecting everyone in the nation. From its first ominous stirrings, renowned journalist Eli Saslow began interviewing a cross-section of Americans, capturing their experiences in real time: An exhausted and anguished EMT risking his life in New York City; a grocery store owner feeding his neighborhood for free in locked-down New Orleans; an overwhelmed coroner in Georgia; a Maryland restaurateur forced to close his family business after forty-six years; an Arizona teacher wrestling with her fears and her obligations to her students; rural citizens adamant that the whole thing is a hoax, and retail workers attacked for asking people to wear masks; patients struggling to breathe and doctors desperately trying to save them. Through Saslow's masterful, empathetic interviewing, we are given a kaleidoscopic picture of a people dealing with the unimaginable. These deeply personal accounts make for cathartic reading, as we see Americans at their worst, and at their resilient best.

This full-length translation of Professor Luria's book introduces to the English speaking world a major document in neuropsychology, summarizing Professor Luria's earlier contributions to that area for nearly a third of a century. It is a monumental contribution. Nothing of this scope exists in the Western literature of this field, with the possible exception of Ajuriaguerra and Hecaen's book (in French) on the cerebral cortex. Professor Luria's book thus marks a further and decisive step toward the eventual coalescence of neurology and psychology, a goal to which only a few laboratories in the East and West have been devoted over the last decades. The book is unique in its organization. The first half deals with observations and interpretations concerning the major syndromes of man's left cerebral hemisphere: those grievous distortions of higher functions traditionally described as aphasia, agnosia, and apraxia. There is also a detailed and brilliant analysis of the syndrome of massive frontal-lobe involvement. The entire second half of the book is given over to a painstaking description of Professor Luria's tests, many of them introduced by himself, and set out in such detail that anyone could repeat them and thus verify Professor Luria's interpretations.

Essays by Oliver Sacks, Jonathan Miller, Stephen Jay Gould, Daniel J. Kevles, & R.C. Lewontin explore forgotten and neglected aspects of the history of science.

Product Description The Prokaryotes is a comprehensive, multi-authored, peer reviewed reference work on Bacteria and Achaea. This fourth edition of The Prokaryotes is organized to cover all taxonomic diversity, using the family level to delineate chapters. Different from other resources, this new Springer product includes not only taxonomy, but also prokaryotic biology and technology of taxa in a broad context. Technological aspects highlight the usefulness of prokaryotes in processes and products, including biocontrol agents and as genetics tools. The content of the expanded fourth edition is divided into two parts: Part 1 contains review chapters dealing with the most important general concepts in molecular, applied and general prokaryote biology; Part 2 describes the known properties of specific taxonomic groups. Two completely new sections have been added to Part 1: bacterial communities and human bacteriology. The bacterial communities section reflects the growing realization that studies on pure cultures of bacteria have led to an incomplete picture of the microbial world for two fundamental reasons: the vast majority of bacteria in soil, water and associated with biological tissues are currently not culturable, and that an understanding of microbial ecology requires knowledge on how different bacterial species interact with each other in their natural environment. The new section on human microbiology deals with bacteria associated with healthy humans and bacterial pathogenesis. Each of the major human diseases caused by bacteria is reviewed, from identifying the pathogens by classical clinical and non-culturing techniques to the biochemical mechanisms of the disease process. The 4th edition of The Prokaryotes is the most complete resource on the biology of prokaryotes. Review From the book reviews:“This book … edited and written by great scientists covers essential contributions on different types of prokaryotic communities as well as on the prokaryotic functions in different environments. … This volume, as well as the whole series, should be available in every large scientific library.” (Ioan I. Ardelean, Bulletin of Micro and Nanoelectrotechnologies, Vol. 5 (3-4), December, 2014) About the Author Eugene Rosenberg, Professor of Microbiology at Tel Aviv University, Israel Edward F. DeLong, Professor at Department of Civil and Environmental Engineering & Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA Stephen Lory, Professor at Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, USA Erko Stackebrandt, German Collection of Microorganisms and Cell Cultures GmbH, DSMZ, Braunschweig, Germany Fabiano Thompson, Professor at Center of Health Sciences, Federal University of Rio de Janeiro, Brazil

Carl Gustav Jung (1875-1961) and Wolfgang Ernst Pauli (1900 - 1958) were two of the greatest thinkers of modern times. Jung is the founder of Analytical Psychology and is one of the best known researchers in the field of Dream Interpretation and Symbolization. Pauli was one of the pioneers of Quantum Physics. In 1945, Pauli received the Nobel Prize in Physics after being nominated by Albert Einstein for his "decisive contribution through his discovery of a new law of Nature, the exclusion principle" involving spin theory underpinning the structure of matter and the whole of chemistry. Together they collaborated on this book that was First published in 1952 in German as Naturerklarung und Psyche. C. G. Jung: Synchronizitat als ein Prinzip akausaler Zusammenhange. W. Pauli: Der Einfluss archetypischer Vorstellungen auf die Bildung naturwissenschaftlicher Theorien bei Kepler. However, our reviewer, himself an eminent professor of mathematics, concludes, "After thoroughly studying their writings for many months now, I have come to see clearly that they are both utterly mad.""