In 1997, Stanley B. Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate. His struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement. In this book, Prusiner tells the remarkable story of his discovery of prions - infectious proteins that replicate and cause disease but surprisingly contain no genetic material - and reveals how superb and meticulous science is actually practiced with talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner's hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer's, Parkinson's, Lou Gehrig's and other devastating diseases of the brain?

" Here, in his own words, is the story of one of the twentieth century's most creative medical innovators, Dr. Henry Heimlich. The thoracic surgeon is best known for having developed the Heimlich Maneuver, the world's easiest-to-learn and most universally known method to save people from choking to death on food or foreign objects. But many don't know about Dr. Heimlich's other life-saving inventions. He is the inventor of the Heimlich Chest Drain Valve, which saved thousands of lives during the Vietnam War, and the Heimlich MicroTrach, which provides a remarkably efficient way for people to take oxygen. In the present decade, Dr. Heimlich has turned his attention to two devastating illnesses for which medicine has not yet found a cure--cancer and HIV. He describes his research and its promise, as well as the controversy and resistance his new ideas have generated from the medical establishment. Interweaving the author's personal life with riveting stories of his numerous medical breakthroughs, this rich memoir provides insights into the workings of a creative mind and the machinations of the American medical system."