Methods in Neuronal Modeling is the first technical handbook on computational neuroscience. Written for researchers and theoreticians alike, it outlines methods and techniques used for simulating on digital computers the functional properties of single neurons from synapses, dendrites, single cells; and small invertebrate networks to large scale neural networks in the mammalian nervous system. The use of new experimental tools such as selective staining methods, membrane patch electrodes, voltage and calcium-dependent dyes, and multielectrode recordings, together with the, advent of universally available powerful computing, makes it possible to construct detailed and realistic models of neuronal systems. Methods in Neuronal Modeling addresses such questions as what can and should be simulated and what techniques should be used; what experimental parameters are crucial for such simulations, and whether these models may be verified experimentally. Chapters cover simulation of passive dendritic trees, compartmental models of single cells including neurons with a number of different ionic channels, calcium current dynamics, simulations of small invertebrate networks, simulations of the mammalian cortex, connectionists' models, and the use of parallel computers in modeling neural networks. Although the chapters were written by several authors, they are uniform in structure and notation. Detailed examples are given to clarify the different approaches. Each chapter concludes with a description of the model discussed and the details of its implementation on the computer. Christof Koch is an Assistant Professor of Computation and Neural Systems at the California Institute of Technology. Idan Segev is a Lecturer in Neurobiology at the Institute of Life Science, Hebrew University of Jerusalem. Methods in Neuronal Modeling inaugurates the new series in Computational Neuroscience, edited by Terrence J. Sejnowski and Tomaso Poggio. A Bradford Book.

In this remarkable book by one of the great psychologists and neurologists of the early twentieth century, Kurt Goldstein presents a summation of his “holistic” theory of the human organism. In the course of his studies on brain-damaged soldiers during the First World War, Goldstein became aware of the failure of contemporary biology and medicine to genuinely understand both the impact of such injuries and the astonishing adjustments that patients made to them. He challenged reductivist approaches that dealt with “localized” symptoms, insisting instead that an organism be analyzed in terms of the totality of its behavior and interaction with its surrounding milieu. He was especially concerned with the breakdown of organization and the failure of central cerebral controls that take place in catastrophic responses to situations such as physical or mental illness. But Goldstein was equally attuned to the amazing powers of the organism to readjust to such devastating losses, if only by withdrawal to a more limited range of activity that it could manage by a redistribution of its reduced energies, thus reclaiming as much wholeness as new circumstances allowed. Goldstein’s concepts in The Organism have had a major impact on philosophical and psychological thought throughout this century, as can be seen in the work of Maurice Merleau-Ponty, Georges Canguilhem, Ernst Cassirer, Ludwig Binswanger, and Roman Jakobson, not to mention the wide-ranging field of Gestalt psychology.