Methods in Neuronal Modeling is the first technical handbook on computational neuroscience. Written for researchers and theoreticians alike, it outlines methods and techniques used for simulating on digital computers the functional properties of single neurons from synapses, dendrites, single cells; and small invertebrate networks to large scale neural networks in the mammalian nervous system. The use of new experimental tools such as selective staining methods, membrane patch electrodes, voltage and calcium-dependent dyes, and multielectrode recordings, together with the, advent of universally available powerful computing, makes it possible to construct detailed and realistic models of neuronal systems. Methods in Neuronal Modeling addresses such questions as what can and should be simulated and what techniques should be used; what experimental parameters are crucial for such simulations, and whether these models may be verified experimentally. Chapters cover simulation of passive dendritic trees, compartmental models of single cells including neurons with a number of different ionic channels, calcium current dynamics, simulations of small invertebrate networks, simulations of the mammalian cortex, connectionists' models, and the use of parallel computers in modeling neural networks. Although the chapters were written by several authors, they are uniform in structure and notation. Detailed examples are given to clarify the different approaches. Each chapter concludes with a description of the model discussed and the details of its implementation on the computer. Christof Koch is an Assistant Professor of Computation and Neural Systems at the California Institute of Technology. Idan Segev is a Lecturer in Neurobiology at the Institute of Life Science, Hebrew University of Jerusalem. Methods in Neuronal Modeling inaugurates the new series in Computational Neuroscience, edited by Terrence J. Sejnowski and Tomaso Poggio. A Bradford Book.

Can we download our consciousness, and if so where should the backup be stored? Why is it that we can drive tired, but not drunk (when sleepiness has caused many more accidents)? What senses would we want to add if we could expand our perception? What types of crimes might we face in an era of neural implants? What would learning look like if humans could transmit thoughts across brains? How can we improve (/ruin) relationships, sex, and intimacy using cross-brain communication? And what can the business world do as it prepares for a world of mind reading? Those and other issues that are at the forefront of current neuroscience research are addressed in a sequence of comical and thought-provoking illustrations by Moran Cerf, professor of neuroscience and business. This graphical visualization of our future makes readers of all ages - kids and adults alike - laugh, and then think.

A neuroscientist demystifies the subject of consciousness in this up-to-date discussion of mind-body connections. How does the firing of neurons give rise to subjective sensations, thoughts, and emotions? How can the disparate domains of mind and body be reconciled? The quest for a scientifically based understanding of consciousness has attracted study and speculation across the ages. In this direct and non-technical discussion of consciousness, Dr. Gerald M. Edelman draws on a lifetime of scientific inquiry into the workings of the brain to formulate answers to the mind-body questions that intrigue every thinking person. Concise and understandable, the book explains pertinent findings of modern neuroscience and describes how consciousness arises in complex brains. Edelman explores the relation of consciousness to causation, to evolution, to the development of the self, and to the origins of feelings, learning, and memory. His analysis of the brain activities underlying consciousness is based on recent remarkable advances in biochemistry, immunology, medical imaging, neuroscience, and evolutionary biology, yet the implications of his book extend farther--beyond the worlds of science and medicine into virtually every area of human inquiry.

In this remarkable book by one of the great psychologists and neurologists of the early twentieth century, Kurt Goldstein presents a summation of his “holistic” theory of the human organism. In the course of his studies on brain-damaged soldiers during the First World War, Goldstein became aware of the failure of contemporary biology and medicine to genuinely understand both the impact of such injuries and the astonishing adjustments that patients made to them. He challenged reductivist approaches that dealt with “localized” symptoms, insisting instead that an organism be analyzed in terms of the totality of its behavior and interaction with its surrounding milieu. He was especially concerned with the breakdown of organization and the failure of central cerebral controls that take place in catastrophic responses to situations such as physical or mental illness. But Goldstein was equally attuned to the amazing powers of the organism to readjust to such devastating losses, if only by withdrawal to a more limited range of activity that it could manage by a redistribution of its reduced energies, thus reclaiming as much wholeness as new circumstances allowed. Goldstein’s concepts in The Organism have had a major impact on philosophical and psychological thought throughout this century, as can be seen in the work of Maurice Merleau-Ponty, Georges Canguilhem, Ernst Cassirer, Ludwig Binswanger, and Roman Jakobson, not to mention the wide-ranging field of Gestalt psychology.