The twenty-first century has seen a breathtaking expansion of statistical methodology, both in scope and influence. 'Data science' and 'machine learning' have become familiar terms in the news, as statistical methods are brought to bear upon the enormous data sets of modern science and commerce. How did we get here? And where are we going? How does it all fit together? Now in paperback and fortified with exercises, this book delivers a concentrated course in modern statistical thinking. Beginning with classical inferential theories - Bayesian, frequentist, Fisherian - individual chapters take up a series of influential topics: survival analysis, logistic regression, empirical Bayes, the jackknife and bootstrap, random forests, neural networks, Markov Chain Monte Carlo, inference after model selection, and dozens more. The distinctly modern approach integrates methodology and algorithms with statistical inference. Each chapter ends with class-tested exercises, and the book concludes with speculation on the future direction of statistics and data science.

McCrimmon, having gotten Grierson's attention, continued: "A breakthrough, you say? If it's in economics, at least it can't be dangerous. Nothing like gene engineering, laser beams, sex hormones or international relations. That's where we don't want any breakthroughs. " (Galbraith, 1. K. (1990) A Tenured Profes sor, Houghton Mifflin; Boston. ) To judge [astronomy] in this way [a narrow utilitarian point of view] demon strates not only how poor we are, but also how small, narrow, and indolent our minds are; it shows a disposition always to calculate the payolTbefore the work, a cold heart and a lack of feeling for everything that is great and honors man. One can unfortunately not deny that such a mode of thinking is not uncommon in our age, and I am convinced that this is closely connected with the catastro phes which have befallen many countries in recent times; do not mistake me, I do not talk of the general lack of concern for science, but of the source from which all this has come, of the tendency to everywhere look out for one's advan tage and to relate everything to one's physical well-being, of the indilTerence towards great ideas, ofthe aversion to any elTort which derives from pure enthu siasm: I believe that such attitudes, if they prevail, can be decisive in catas trophes of the kind we have experienced. [Gauss, K. F. : Astronomische An trittsvorlesung (cited from Buhler, W. K. (1981) Gauss: A Biographical Study, Springer: New York)].