A history of the T4 program, or "euthanasia program", in Nazi Germany - that is, the murder of handicapped persons by the Nazis. This program was preceded by the politicization of science, which incorporated popular prejudices into "scientific" theories and declared some individuals and even "racial" groups, like Jews and Gypsies, to be "valueless"; by the eugenic movement; and by the misuse of scientific hypotheses by politicians. The policy of exclusion of the "racially inferior" stood at the center of the Nazi utopia. The "euthanasia program", implemented in 1939-40, paved the way for the mass extermination of Jews and Gypsies in 1942-44. Many of those involved in the T4 program (e.g. Franz Stangl) were later involved in the operation of the death camps. Special attention is devoted to the murder of handicapped Jews. These, progressively excluded from the public welfare system and from the medical institutions, were concentrated in 1939-40 in special Jewish hospitals and later killed in the course of the "euthanasia program".

All investigators funded by the National Institutes of Health are now required to receive training about the ethics of clinical research. Based on a course taught by the editors at NIH, Ethical and Regulatory Aspects of Clinical Research is the first book designed to help investigators meet this new requirement. The book begins with the history of human subjects research and guidelines instituted since World War II. It then covers various stages and components of the clinical trial process: designing the trial, recruiting participants, ensuring informed consent, studying special populations, and conducting international research. Concluding chapters address conflicts of interest, scientific misconduct, and challenges to the IRB system. The appendix provides sample informed consent forms. This book will be used in undergraduate courses on research ethics and in schools of medicine and public health by students who are or will be carrying out clinical research. Professionals in need of such training and bioethicists also will be interested.